DegronMD - Q6ZMM2(ADAMTSL5)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A360T	TCGA-19-1787	GBM	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1111
p.A340V	TCGA-2H-A9GR	ESCA	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1944
p.L433V	TCGA-56-7222	LUSC	TCGA	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.6765
p.R359H	TCGA-77-A5G7	LUSC	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1389
p.R359L	TCGA-78-7159	LUAD	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1389
p.P422S	TCGA-CK-4951	COAD	TCGA	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.1111
p.R357H	TCGA-CM-5348	COAD	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1944
p.R357H	TCGA-D1-A1NS	UCEC	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1944
p.H424R	DO51920	BLCA	ICGC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.1667
p.V337G	DO218428	BRCA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1111
p.P432S	DO10582	COAD	ICGC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.6752
p.P349H	DO222769	COCA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation altering degron motif	0.7694
p.V337L	DO233230	GACA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1111
p.T348A	DO233634	GACA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation altering degron motif	0.7139
p.P428L	DO233767	GACA	ICGC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.2778
p.P362T	DO228978	LICA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.0556
p.P341H	DO229018	LICA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.2222
p.P361Q	DO229019	LICA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.0833
p.P426T	DO229022	LICA	ICGC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.2222
p.D435E	DO229045	LICA	ICGC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.5647
p.L443V	DO26842	LUSC	ICGC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.1111
p.P345H	DO49138	PACA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation altering degron motif	0.7694
p.A356V	DO38404	STAD	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.2222
p.H424Y	DO229216	THCA	ICGC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.1667
p.A343V	DO43963	UCEC	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.2778
p.P339L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1667
p.R432C	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.8301
p.R432C	ACH-000605	Esophageal Cancer	CCLE	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.8301
p.R432C	TE-6	oesophagus	COSMIC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.8301
p.L444P	SIDM00333	Endometrial Carcinoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.0833
p.L444P	ACH-000988	Endometrial/Uterine Cancer	CCLE	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.0833
p.L444P	MFE-319	endometrium	COSMIC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.0833
p.R432H	SIDM00837	Colorectal Carcinoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.8244
p.R432H	SIDM01641	Non-Cancerous	GDSC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.8244
p.R432H	SIDM01012	Other Blood Cancers	GDSC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.8244
p.R432H	SIDM01724	Melanoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.8244
p.T356I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.2222
p.T356I	ACH-000672	Lung Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.2222
p.T356I	IA-LM	lung	COSMIC	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.2222
p.D425V	SIDM01608	Endometrial Carcinoma	GDSC	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.1944
p.D425V	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation rewiring degron network	0.1944
p.C353R	ACH-000434	Lung Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.3056
p.C353R	ACH-001054	Brain Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.3056
p.R434W	ACH-000971	Colon/Colorectal Cancer	CCLE	LAPHRD	LIG_APCC_ABBA_1	430:435	Mutation altering degron motif	0.7523
p.T356P	ACH-001497	Esophageal Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.2222
p.R357C	ACH-001786	Colon/Colorectal Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	345:352	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTSL5

UniProt ID: Q6ZMM2

Entrez ID: 339366

Protein name: ADAMTS-like protein 5 (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTSL5 in