DegronMD

Uniprot ID: Q6ZMM2

Source protein: ADAMTS-like protein 5

Source gene: ADAMTSL5

Class: DEG_SCF_FBW7_1

Location: 345:352

E3 ligase: FBXW7

DEGRON score: 0.8033

ASA_SCORE: 86.0125

COIL: 0.9164

CONS_SCORE: 0.5169

DSS_SCORE: 0.7076

HELIX: 0.0398

FCONS_SCORE: 0.9648

RIG_SCORE: 0.6122

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A360T	TCGA-19-1787	GBM	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	0.1111
p.A340V	TCGA-2H-A9GR	ESCA	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	0.1944
p.R359H	TCGA-77-A5G7	LUSC	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	0.1389
p.R359L	TCGA-78-7159	LUAD	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	0.1389
p.R357H	TCGA-CM-5348	COAD	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	0.1944
p.R357H	TCGA-D1-A1NS	UCEC	TCGA	PAVTPAQT	DEG_SCF_FBW7_1	0.1944
p.V337G	DO218428	BRCA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.1111
p.P349H	DO222769	COCA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.7694
p.V337L	DO233230	GACA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.1111
p.T348A	DO233634	GACA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.7139
p.P362T	DO228978	LICA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.0556
p.P341H	DO229018	LICA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.2222
p.P361Q	DO229019	LICA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.0833
p.P345H	DO49138	PACA	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.7694
p.A356V	DO38404	STAD	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.2222
p.A343V	DO43963	UCEC	ICGC	PAVTPAQT	DEG_SCF_FBW7_1	0.2778
p.P339L	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PAVTPAQT	DEG_SCF_FBW7_1	0.1667
p.T356I	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	PAVTPAQT	DEG_SCF_FBW7_1	0.2222
p.T356I	ACH-000672	Lung Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	0.2222
p.T356I	IA-LM	lung	COSMIC	PAVTPAQT	DEG_SCF_FBW7_1	0.2222
p.C353R	ACH-000434	Lung Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	0.3056
p.C353R	ACH-001054	Brain Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	0.3056
p.T356P	ACH-001497	Esophageal Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	0.2222
p.R357C	ACH-001786	Colon/Colorectal Cancer	CCLE	PAVTPAQT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMM2	ADAMTS-like protein 5	DEG_SCF_FBW7_1	345:352	PAVTPAQT	FBXW7	0.8033	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons