DegronMD

Uniprot ID: P23229

Source protein: Integrin alpha-6

Source gene: ITGA6

Class: DEG_ODPH_VHL_1

Location: 821:834

E3 ligase: VHL

DEGRON score: 0.7689

ASA_SCORE: 47.1929

COIL: 0.2404

CONS_SCORE: 0.4249

DSS_SCORE: 0.0941

HELIX: 0.0111

FCONS_SCORE: 0.7878

RIG_SCORE: 0.9018

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G827E	TCGA-18-3409	LUSC	TCGA	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.7199
p.E817K	TCGA-2W-A8YY	CESC	TCGA	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.2222
p.E817K	TCGA-AX-A2HC	UCEC	TCGA	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.2222
p.Q818K	TCGA-A4-7734	KIRP	TCGA	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.25
p.L831V	DO51918	BLCA	ICGC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.6765
p.S839L	DO566	BLCA	ICGC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.1944
p.P821L	DO3406	BRCA	ICGC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.7582
p.S816G	DO228308	MALY	ICGC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.1944
p.I837T	SIDM00878	Breast Carcinoma	GDSC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.25
p.I837T	ACH-000930	Breast Cancer	CCLE	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.25
p.I837T	HCC1569	breast	COSMIC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.25
p.I832T	HCC1569	breast	COSMIC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.7078
p.G842V	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.1111
p.N817S	CHSA0108	bone	COSMIC	LAPITAKAKVVIEL	DEG_ODPH_VHL_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23229	Integrin alpha-6	DEG_ODPH_VHL_1	821:834	LAPITAKAKVVIEL	VHL	0.7689	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons