DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_ODPH_VHL_1

Location: 1542:1555

E3 ligase: VHL

DEGRON score: 0.937

ASA_SCORE: 101.4429

COIL: 0.9451

CONS_SCORE: 0.2288

DSS_SCORE: 0.5828

HELIX: 0.0243

FCONS_SCORE: 0.7196

RIG_SCORE: 0.6967

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1557P	DO228093	EOPC	ICGC	LAPKEALIPPAMTV	DEG_ODPH_VHL_1	0.2778
p.K1560N	DO14566	HNSC	ICGC	LAPKEALIPPAMTV	DEG_ODPH_VHL_1	0.3056
p.S1557F	DO37823	SKCM	ICGC	LAPKEALIPPAMTV	DEG_ODPH_VHL_1	0.2778
p.P1558R	DO50136	STAD	ICGC	LAPKEALIPPAMTV	DEG_ODPH_VHL_1	0.25
p.M1553V	DO43755	UCEC	ICGC	LAPKEALIPPAMTV	DEG_ODPH_VHL_1	0.6097
p.T1554A	PE/CA-PJ15	upper_aerodigestive_tract	COSMIC	LAPKEALIPPAMTV	DEG_ODPH_VHL_1	0.6028
p.K1537N	OACp4C	oesophagus	COSMIC	LAPKEALIPPAMTV	DEG_ODPH_VHL_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_ODPH_VHL_1	1542:1555	LAPKEALIPPAMTV	VHL	0.937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons