DegronMD

Uniprot ID: Q8IV08

Source protein: 5'-3' exonuclease PLD3

Source gene: PLD3

Class: DEG_ODPH_VHL_1

Location: 154:165

E3 ligase: VHL

DEGRON score: 0.6347

ASA_SCORE: 28.6333

COIL: 0.2812

CONS_SCORE: 0.6044

DSS_SCORE: 0.4562

HELIX: 0.1047

FCONS_SCORE: 1.2615

RIG_SCORE: 0.7393

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P168R	TCGA-2Y-A9H1	LIHC	TCGA	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.25
p.P168R	DO219521	LIHC	ICGC	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.25
p.R162C	TCGA-DC-6154	READ	TCGA	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.719
p.R162C	DO227569	PBCA	ICGC	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.719
p.R162C	DO36523	READ	ICGC	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.719
p.R162C	SIDM01313	Colorectal Carcinoma	GDSC	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.719
p.Q150H	DO228986	LICA	ICGC	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.2222
p.Q150H	DO229045	LICA	ICGC	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.2222
p.G144A	SIDM00545	Melanoma	GDSC	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.0556
p.R162H	ACH-001707	Leukemia	CCLE	LAPKGVNVRIAV	DEG_ODPH_VHL_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV08	5'-3' exonuclease PLD3	DEG_ODPH_VHL_1	154:165	LAPKGVNVRIAV	VHL	0.6347	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons