DegronMD

Uniprot ID: P49796

Source protein: Regulator of G-protein signaling 3

Source gene: RGS3

Class: DEG_ODPH_VHL_1

Location: 546:557

E3 ligase: VHL

DEGRON score: 0.5327

ASA_SCORE: 46.3667

COIL: 0.3853

CONS_SCORE: 0.5507

DSS_SCORE: 0.0192

HELIX: 0.0153

FCONS_SCORE: 1.1038

RIG_SCORE: 0.9293

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A566V	TCGA-06-5416	GBM	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.0833
p.R567Q	TCGA-38-4631	LUAD	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.0556
p.A547T	TCGA-CG-5723	STAD	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7139
p.G541C	TCGA-D3-A3CE	SKCM	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.1944
p.P554H	TCGA-DU-7294	LGG	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.6583
p.R550L	DO218998	BLCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.8428
p.R550L	OV-90	ovary	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.8428
p.Q557R	DO4257	BRCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7329
p.T552I	DO8858	COAD	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7078
p.R559C	DO22237	LGG	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.2778
p.D554Y	DO228985	LICA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7325
p.Q557H	DO26536	LUSC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7582
p.K546N	DO51511	PACA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.6918
p.M553I	DO229459	SKCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7618
p.G562W	DO37916	SKCM	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.1944
p.G562W	RKO	large_intestine	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.1944
p.K558N	DO43186	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.3056
p.R550Q	DO43154	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7329
p.D554N	DO43755	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.6932
p.V550I	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	SIDM00257	Neuroblastoma	GDSC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	ACH-000953	Leukemia	CCLE	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	ACH-002280	Neuroblastoma	CCLE	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	NB13	autonomic_ganglia	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.G541D	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.1944
p.L558P	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.3056
p.A567V	HEC-1	endometrium	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.0556
p.P565T	HCT-15	large_intestine	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.1111
p.V545M	MZ7-mel	skin	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.75
p.T549M	HCT-15	large_intestine	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPKVLVFPVFV

Degron related mutations and impact score

Drug responses associated with RGS3 mutations

All proteins holding degron of LAPKVLVFPVFV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49796	Regulator of G-protein signaling 3	DEG_ODPH_VHL_1	546:557	LAPKVLVFPVFV	VHL	0.5327	More...