DegronMD

Uniprot ID: P49796

Source protein: Regulator of G-protein signaling 3

Source gene: RGS3

Class: DEG_ODPH_VHL_1

Location: 546:557

E3 ligase: VHL

DEGRON score: 0.5327

ASA_SCORE: 46.3667

COIL: 0.3853

CONS_SCORE: 0.5507

DSS_SCORE: 0.0192

HELIX: 0.0153

FCONS_SCORE: 1.1038

RIG_SCORE: 0.9293

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R550L	DO218998	BLCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.8428
p.R550L	OV-90	ovary	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.8428
p.M553I	DO229459	SKCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7618
p.Q557H	DO26536	LUSC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7582
p.V545M	MZ7-mel	skin	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.75
p.T549M	HCT-15	large_intestine	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7423
p.Q557R	DO4257	BRCA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7329
p.R550Q	DO43154	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7329
p.D554Y	DO228985	LICA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7325
p.A547T	TCGA-CG-5723	STAD	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7139
p.T552I	DO8858	COAD	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.7078
p.D554N	DO43755	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.6932
p.K546N	DO51511	PACA	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.6918
p.P554H	TCGA-DU-7294	LGG	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.6583
p.V550I	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	SIDM00257	Neuroblastoma	GDSC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	ACH-000953	Leukemia	CCLE	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	ACH-002280	Neuroblastoma	CCLE	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	NB13	autonomic_ganglia	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.V550I	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.5965
p.K558N	DO43186	UCEC	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.3056
p.L558P	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.3056
p.R559C	DO22237	LGG	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.2778
p.G541C	TCGA-D3-A3CE	SKCM	TCGA	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.1944
p.G562W	DO37916	SKCM	ICGC	LAPKVLVFPVFV	DEG_ODPH_VHL_1	0.1944

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Drug responses associated with RGS3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of LAPKVLVFPVFV

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49796	Regulator of G-protein signaling 3	DEG_ODPH_VHL_1	546:557	LAPKVLVFPVFV	VHL	0.5327	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPKVLVFPVFV

Degron related mutations and impact score

Drug responses associated with RGS3 mutations

All proteins holding degron of LAPKVLVFPVFV