DegronMD

Uniprot ID: E9PAV3

Source protein: Nascent polypeptide-associated complex subunit alpha, muscle-specific form

Source gene: NACA

Class: DEG_ODPH_VHL_1

Location: 309:322

E3 ligase: VHL

DEGRON score: 0.7144

ASA_SCORE: 89.7357

COIL: 0.9114

CONS_SCORE: 0.3706

DSS_SCORE: 0.4424

HELIX: 0.0344

FCONS_SCORE: 1.1577

RIG_SCORE: 0.6955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G327C	TCGA-AA-3864	COAD	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1944
p.G327C	DO8490	COAD	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1944
p.A330V	TCGA-AD-6889	COAD	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1111
p.A330V	DO8463	COAD	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1111
p.P311H	TCGA-AX-A1CE	UCEC	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.7694
p.P311H	DO42280	UCEC	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.7694
p.S329G	TCGA-BR-4363	STAD	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1389
p.S329G	DO38815	STAD	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1389
p.S316Y	TCGA-BS-A0UF	UCEC	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.6009
p.S316Y	DO41488	UCEC	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.6009
p.P302L	TCGA-D9-A1JX	SKCM	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1389
p.P302L	DO37711	SKCM	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1389
p.F301V	TCGA-EO-A22X	UCEC	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1111
p.F301V	DO43907	UCEC	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1111
p.P302S	TCGA-FR-A3YO	SKCM	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1389
p.P302S	DO37419	SKCM	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1389
p.S304Y	TCGA-IB-7651	PAAD	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1944
p.S304Y	TCGA-ND-A4WC	UCS	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1944
p.S304Y	DO46657	PAAD	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.1944
p.L331F	TCGA-K4-A3WS	BLCA	TCGA	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.0833
p.L331F	DO480	BLCA	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.0833
p.S307P	DO233869	GACA	ICGC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.2778
p.P299R	SIDM01664	Prostate Carcinoma	GDSC	LAPLHQSSFGSVQL	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
E9PAV3	Nascent polypeptide-associated complex subunit alpha, muscle-specific form	DEG_ODPH_VHL_1	309:322	LAPLHQSSFGSVQL	VHL	0.7144	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons