DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPLPFPGLSKLNL
Uniprot ID:
Q99581
Source protein:
Protein FEV
Source gene:
FEV
Class:
DEG_ODPH_VHL_1
Location:
167:180
E3 ligase:
VHL
DEGRON score:
0.9579
ASA_SCORE:
70.1
COIL:
0.8243
CONS_SCORE:
0.57
DSS_SCORE:
0.0738
HELIX:
0.1424
FCONS_SCORE:
1.3016
RIG_SCORE:
0.7793
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FEV mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPLPFPGLSKLNL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q99581
Protein FEV
DEG_ODPH_VHL_1
167:180
LAPLPFPGLSKLNL
VHL
0.9579
More...