DegronMD

Uniprot ID: Q96QU1

Source protein: Protocadherin-15

Source gene: PCDH15

Class: DEG_ODPH_VHL_1

Location: 1765:1776

E3 ligase: VHL

DEGRON score: 0.969

ASA_SCORE: 84.425

COIL: 0.9515

CONS_SCORE: 0.3467

DSS_SCORE: 0.5172

HELIX: 0.0221

FCONS_SCORE: 1.0388

RIG_SCORE: 0.5798

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1761H	TCGA-A6-3810	COAD	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2222
p.I1755V	TCGA-AA-3966	COAD	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0556
p.P1775S	TCGA-D3-A8GL	SKCM	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6752
p.P1785H	TCGA-DF-A2KU	UCEC	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0833
p.P1769H	TCGA-DF-A2KU	UCEC	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6583
p.S1784Y	TCGA-EI-6917	READ	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1111
p.P1757S	TCGA-FR-A8YC	SKCM	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1111
p.P1757T	TCGA-NJ-A4YF	LUAD	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1111
p.A1763D	TCGA-O2-A52Q	LUSC	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2778
p.A1763D	NCI-H1105	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2778
p.P1783S	TCGA-VS-A958	CESC	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389
p.P1783L	TCGA-WE-AAA0	SKCM	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389
p.P1758S	TCGA-YG-AA3N	SKCM	TCGA	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389
p.A1761V	DO51878	BLCA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2222
p.A1761V	DO223286	UCEC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2222
p.E1779K	DO219064	BLCA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.25
p.E1779K	ACH-002509	Skin Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.25
p.P1778S	DO51639	CESC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2778
p.K1772N	DO8882	COAD	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6918
p.K1766N	DO222798	COCA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6918
p.K1766N	DO42400	UCEC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6918
p.K1766N	ACH-000993	Endometrial/Uterine Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6918
p.P1757H	DO234216	ESAD	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1111
p.K1771R	DO234325	ESAD	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7237
p.K1771T	DO234373	ESAD	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7306
p.K1771N	DO234377	ESAD	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6918
p.K1771N	DO41542	UCEC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6918
p.K1771N	SIDM01588	Endometrial Carcinoma	GDSC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6918
p.G1775E	DO233830	GACA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7199
p.G1775E	DO229459	SKCA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7199
p.S1765C	DO22812	LICA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7541
p.A1758P	DO23428	LINC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389
p.P1762L	DO25659	LUAD	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.25
p.P1762L	SW684	soft_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.25
p.P1774Q	DO24692	LUAD	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7035
p.P1759T	DO26830	LUSC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.N1782K	DO50095	LUSC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.C1771Y	DO26794	LUSC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7087
p.A1758D	DO219219	LUSC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389
p.T1781N	DO27136	LUSC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1944
p.L1767M	DO52686	MALY	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.711
p.L1785H	DO222504	MELA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0833
p.P1765S	DO222532	MELA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6752
p.S1773L	DO222710	MELA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7667
p.S1773L	DO47619	SKCM	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7667
p.S1773L	DO51259	SKCM	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7667
p.P1756L	DO229162	NKTL	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0833
p.T1783R	DO28068	OV	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389
p.S1779Y	DO36881	READ	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.25
p.P1770S	DO50287	SKCM	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6752
p.P1776L	DO229234	THCA	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7582
p.P1776L	ETK-1	biliary_tract	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7582
p.P1780H	DO223286	UCEC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2222
p.R1764I	DO43041	UCEC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.3056
p.G1776S	DO52402	UCEC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6993
p.G1776S	DO43755	UCEC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6993
p.G1756D	DO41488	UCEC	ICGC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0833
p.A1773S	SIDM00984	Other Blood Cancers	GDSC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7588
p.A1773S	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7588
p.Q1763R	SIDM00660	Colorectal Carcinoma	GDSC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2778
p.Q1763R	LS-411N	large_intestine	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2778
p.Y1757C	ACH-000687	Lymphoma	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1111
p.A1765D	ACH-000780	Lung Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7793
p.A1765D	NCI-H1105	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7793
p.S1782C	ACH-000888	Lung Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.S1782C	NCI-H1793	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.A1768P	ACH-000912	Lung Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7503
p.Q1758R	ACH-000985	Colon/Colorectal Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389
p.L1767V	ACH-001402	Cervical Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6765
p.L1767V	SW756	cervix	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6765
p.A1768S	ACH-001452	Leukemia	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7588
p.V1759E	ACH-001533	Lymphoma	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.V1759L	ACH-001533	Lymphoma	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.P1769S	ACH-001696	Head and Neck Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.5641
p.P1771L	ACH-001858	Bile Duct Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7582
p.P1771L	ACH-002237	Bile Duct Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7582
p.P1771L	ETK-1	biliary_tract	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7582
p.P1771L	SW684	soft_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7582
p.P1764L	ACH-002029	Head and Neck Cancer	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.3056
p.P1764L	ACH-002309	Sarcoma	CCLE	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.3056
p.P1764L	SW684	soft_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.3056
p.P1756T	NCI-H1793	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0833
p.S1768F	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7982
p.A1786V	CCK-81	large_intestine	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0556
p.P1766L	ETK-1	biliary_tract	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7582
p.P1778L	ETK-1	biliary_tract	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.2778
p.A1772S	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7588
p.S1779C	NCI-H1793	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.25
p.A1760D	NCI-H1105	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1944
p.P1759L	SK-MEL-5	skin	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.P1759L	SW684	soft_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.P1786L	SK-MEL-5	skin	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0556
p.A1766S	BONNA-12	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7588
p.A1772D	NCI-H1105	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7793
p.S1784C	NCI-H1793	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1111
p.A1770D	NCI-H1105	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7793
p.L1774V	SW756	cervix	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6765
p.P1758T	NCI-H1793	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389
p.L1765V	SW756	cervix	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6765
p.C1760F	NCI-H250	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1944
p.L1772V	SW756	cervix	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6765
p.P1757L	SK-MEL-5	skin	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1111
p.L1762V	SW756	cervix	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.25
p.S1759C	NCI-H1793	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1667
p.S1770F	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.7982
p.Q1762R	LS-411N	large_intestine	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.25
p.P1769L	SW684	soft_tissue	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6471
p.P1769L	ETK-1	biliary_tract	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.6471
p.Q1756R	LS-411N	large_intestine	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.0833
p.C1758F	NCI-H250	lung	COSMIC	LAPPPDISPFSL	DEG_ODPH_VHL_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPPPDISPFSL

Degron related mutations and impact score

Drug responses associated with PCDH15 mutations

All proteins holding degron of LAPPPDISPFSL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96QU1	Protocadherin-15	DEG_ODPH_VHL_1	1765:1776	LAPPPDISPFSL	VHL	0.969	More...