DegronMD

Uniprot ID: Q68DA7

Source protein: Formin-1

Source gene: FMN1

Class: DEG_ODPH_VHL_1

Location: 951:963

E3 ligase: VHL

DEGRON score: 0.9646

ASA_SCORE: 74.9769

COIL: 0.8814

CONS_SCORE: 0.5584

DSS_SCORE: 0.6496

HELIX: 0.0889

FCONS_SCORE: 0.904

RIG_SCORE: 0.5577

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K946N	TCGA-66-2754	LUSC	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1944
p.V951M	TCGA-AA-3947	COAD	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.7208
p.V951M	DO8192	COAD	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.7208
p.T942M	TCGA-BK-A13B	UCEC	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.0833
p.V954M	TCGA-BR-4201	STAD	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.7208
p.V954M	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.7208
p.R943Q	TCGA-EI-6917	READ	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1111
p.N969D	TCGA-EO-A22R	UCEC	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1667
p.N969D	DO42713	UCEC	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1667
p.D956H	DO218059	BRCA	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.7688
p.L952F	DO228268	BRCA	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.6981
p.R957Q	DO36881	READ	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.7329
p.R957Q	DO50076	UCEC	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.7329
p.P947L	SIDM00450	Acute Myeloid Leukemia	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.2222
p.P947L	SIDM00496	Thyroid Gland Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.2222
p.P947L	HTC-C3	thyroid	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.2222
p.R972Q	SIDM01196	Hepatocellular Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.0833
p.R972Q	SIDM01146	Gastric Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.0833
p.R972Q	ACH-000422	Liver Cancer	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.0833
p.R972Q	ACH-000932	Gastric Cancer	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.0833
p.R972Q	NCI-SNU-1	stomach	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.0833
p.R972Q	SNU-475	liver	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.0833
p.C970Y	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1389
p.C970Y	SIDM00214	Colorectal Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1389
p.C970Y	SIDM00612	Glioma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1389
p.C970Y	SIDM00609	Kidney Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1389
p.C970Y	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1389
p.C970Y	SIDM01378	Ovarian Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.1389
p.S967P	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.2222
p.S967P	ACH-001498	Lymphoma	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.2222
p.S967P	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.2222
p.P949Q	SIDM01689	B-Lymphoblastic Leukemia	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.2778
p.R972G	ACH-001412	Bladder Cancer	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.0833
p.A952S	ACH-001422	Prostate Cancer	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.7588
p.L964F	JHH-4	liver	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPPPPPGLFFGL

Degron related mutations and impact score

Drug responses associated with FMN1 mutations

All proteins holding degron of LAPPPPPGLFFGL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DA7	Formin-1	DEG_ODPH_VHL_1	951:963	LAPPPPPGLFFGL	VHL	0.9646	More...