DegronMD - Q68DA7(FMN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K946N	TCGA-66-2754	LUSC	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1944
p.V951M	TCGA-AA-3947	COAD	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.7208
p.V951M	DO8192	COAD	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.7208
p.S215N	TCGA-AA-3977	COAD	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7069
p.S215N	DO8730	COAD	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.7069
p.P209H	TCGA-AX-A2HC	UCEC	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6583
p.P209H	DO41572	UCEC	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6583
p.T942M	TCGA-BK-A13B	UCEC	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.0833
p.V954M	TCGA-BR-4201	STAD	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.7208
p.V954M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.7208
p.P206H	TCGA-DA-A1IB	SKCM	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.3056
p.P206H	TCGA-EE-A183	SKCM	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.3056
p.P206H	DO37715	SKCM	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.3056
p.P206H	DO38033	SKCM	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.3056
p.R208M	TCGA-EE-A29N	SKCM	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8632
p.R208M	TCGA-EY-A1GD	UCEC	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8632
p.R208M	DO38001	SKCM	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8632
p.R208M	DO42129	UCEC	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.8632
p.R943Q	TCGA-EI-6917	READ	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1111
p.N969D	TCGA-EO-A22R	UCEC	TCGA	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1667
p.N969D	DO42713	UCEC	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1667
p.A219T	TCGA-EO-A22X	UCEC	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.2222
p.A219T	DO43907	UCEC	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.2222
p.P222L	TCGA-QQ-A8VF	SARC	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.P222L	DO220258	SARC	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.D956H	DO218059	BRCA	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.7688
p.L952F	DO228268	BRCA	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.6981
p.C197S	DO23537	LIRI	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0556
p.W212S	DO222727	MELA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6763
p.R957Q	DO36881	READ	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.7329
p.R957Q	DO50076	UCEC	ICGC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.7329
p.S198P	DO219881	SKCA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.S198P	DO229499	SKCA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.S198P	DO229453	SKCA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.S198P	DO218842	SKCA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.P947L	SIDM00450	Acute Myeloid Leukemia	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.2222
p.P947L	SIDM00496	Thyroid Gland Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.2222
p.P947L	HTC-C3	thyroid	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.2222
p.P222Q	SIDM00608	Plasma Cell Myeloma	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.P222Q	KMS-11	haematopoietic and lymphoid tissue	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.R972Q	SIDM01196	Hepatocellular Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.0833
p.R972Q	SIDM01146	Gastric Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.0833
p.R972Q	ACH-000422	Liver Cancer	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.0833
p.R972Q	ACH-000932	Gastric Cancer	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.0833
p.R972Q	NCI-SNU-1	stomach	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.0833
p.R972Q	SNU-475	liver	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.0833
p.S198C	SIDM01114	Non-Cancerous	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.S198C	ACH-001383	Prostate Cancer	CCLE	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.S198C	PWR-1E	prostate	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.S198F	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.S198F	ACH-000334	Lymphoma	CCLE	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.S198F	DB	haematopoietic and lymphoid tissue	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.0833
p.P209S	SIDM00888	Other Solid Cancers	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.5641
p.P209S	ACH-000055	Brain Cancer	CCLE	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.5641
p.P209S	D-283MED	central nervous system	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.5641
p.C970Y	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1389
p.C970Y	SIDM00214	Colorectal Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1389
p.C970Y	SIDM00612	Glioma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1389
p.C970Y	SIDM00609	Kidney Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1389
p.C970Y	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1389
p.C970Y	SIDM01378	Ovarian Carcinoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.1389
p.H200Y	SIDM00526	Chronic Myelogenous Leukemia	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.H200Y	ACH-000072	Leukemia	CCLE	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.H200Y	MEG-01	haematopoietic and lymphoid tissue	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation rewiring degron network	0.1389
p.S967P	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.2222
p.S967P	ACH-001498	Lymphoma	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.2222
p.S967P	Farage	haematopoietic and lymphoid tissue	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.2222
p.Q207E	SIDM00115	Head and Neck Carcinoma	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6744
p.Q207E	PCI-6A	upper aerodigestive tract	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	207:215	Mutation altering degron motif	0.6744
p.P949Q	SIDM01689	B-Lymphoblastic Leukemia	GDSC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.2778
p.R972G	ACH-001412	Bladder Cancer	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.0833
p.A952S	ACH-001422	Prostate Cancer	CCLE	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation altering degron motif	0.7588
p.L964F	JHH-4	liver	COSMIC	LAPPPPPGLFFGL	DEG_ODPH_VHL_1	951:963	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FMN1

UniProt ID: Q68DA7

Entrez ID: 342184

Protein name: Formin-1 (Limb deformity protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FMN1 in