DegronMD

Uniprot ID: Q68DA7

Source protein: Formin-1

Source gene: FMN1

Class: DEG_APCC_DBOX_1

Location: 207:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9831

ASA_SCORE: 78.4222

COIL: 0.5807

CONS_SCORE: 0.4956

DSS_SCORE: 0.3726

HELIX: 0.0824

FCONS_SCORE: 1.0364

RIG_SCORE: 0.7974

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S215N	TCGA-AA-3977	COAD	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	0.7069
p.S215N	DO8730	COAD	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.7069
p.P209H	TCGA-AX-A2HC	UCEC	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	0.6583
p.P209H	DO41572	UCEC	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.6583
p.P206H	TCGA-DA-A1IB	SKCM	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	0.3056
p.P206H	TCGA-EE-A183	SKCM	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	0.3056
p.P206H	DO37715	SKCM	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.3056
p.P206H	DO38033	SKCM	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.3056
p.R208M	TCGA-EE-A29N	SKCM	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	0.8632
p.R208M	TCGA-EY-A1GD	UCEC	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	0.8632
p.R208M	DO38001	SKCM	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.8632
p.R208M	DO42129	UCEC	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.8632
p.A219T	TCGA-EO-A22X	UCEC	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	0.2222
p.A219T	DO43907	UCEC	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.2222
p.P222L	TCGA-QQ-A8VF	SARC	TCGA	TRPNLWVLE	DEG_APCC_DBOX_1	0.1389
p.P222L	DO220258	SARC	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.1389
p.C197S	DO23537	LIRI	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0556
p.W212S	DO222727	MELA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.6763
p.S198P	DO219881	SKCA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.S198P	DO229499	SKCA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.S198P	DO229453	SKCA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.S198P	DO218842	SKCA	ICGC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.P222Q	SIDM00608	Plasma Cell Myeloma	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	0.1389
p.P222Q	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	0.1389
p.S198C	SIDM01114	Non-Cancerous	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.S198C	ACH-001383	Prostate Cancer	CCLE	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.S198C	PWR-1E	prostate	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.S198F	SIDM00886	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.S198F	ACH-000334	Lymphoma	CCLE	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.S198F	DB	haematopoietic_and_lymphoid_tissue	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	0.0833
p.P209S	SIDM00888	Other Solid Cancers	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	0.5641
p.P209S	ACH-000055	Brain Cancer	CCLE	TRPNLWVLE	DEG_APCC_DBOX_1	0.5641
p.P209S	D-283MED	central_nervous_system	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	0.5641
p.H200Y	SIDM00526	Chronic Myelogenous Leukemia	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	0.1389
p.H200Y	ACH-000072	Leukemia	CCLE	TRPNLWVLE	DEG_APCC_DBOX_1	0.1389
p.H200Y	MEG-01	haematopoietic_and_lymphoid_tissue	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	0.1389
p.Q207E	SIDM00115	Head and Neck Carcinoma	GDSC	TRPNLWVLE	DEG_APCC_DBOX_1	0.6744
p.Q207E	PCI-6A	upper_aerodigestive_tract	COSMIC	TRPNLWVLE	DEG_APCC_DBOX_1	0.6744

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRPNLWVLE

Degron related mutations and impact score

Drug responses associated with FMN1 mutations

All proteins holding degron of TRPNLWVLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q68DA7	Formin-1	DEG_APCC_DBOX_1	207:215	TRPNLWVLE	APC,CDC20,FZR1	0.9831	More...