DegronMD

Uniprot ID: P13569

Source protein: Cystic fibrosis transmembrane conductance regulator

Source gene: CFTR

Class: DEG_ODPH_VHL_1

Location: 796:807

E3 ligase: VHL

DEGRON score: 0.5496

ASA_SCORE: 92.2

COIL: 0.6646

CONS_SCORE: 0.3267

DSS_SCORE: 0.3599

HELIX: 0.2841

FCONS_SCORE: 0.9361

RIG_SCORE: 0.7864

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A789S	TCGA-AP-A051	UCEC	TCGA	LAPQANLTELDI	DEG_ODPH_VHL_1	0.1389
p.A789S	TCGA-AX-A0J0	UCEC	TCGA	LAPQANLTELDI	DEG_ODPH_VHL_1	0.1389
p.Q799K	TCGA-CV-7415	HNSC	TCGA	LAPQANLTELDI	DEG_ODPH_VHL_1	0.5833
p.Q799K	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.5833
p.Q799K	SIDM00153	T-Lymphoblastic Leukemia	GDSC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.5833
p.Q799K	ACH-000964	Leukemia	CCLE	LAPQANLTELDI	DEG_ODPH_VHL_1	0.5833
p.Q799K	ACH-001127	Leukemia	CCLE	LAPQANLTELDI	DEG_ODPH_VHL_1	0.5833
p.Q799K	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.5833
p.P798L	TCGA-Z2-A8RT	SKCM	TCGA	LAPQANLTELDI	DEG_ODPH_VHL_1	0.7582
p.P798L	DO51301	SKCM	ICGC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.7582
p.E812Q	DO51878	BLCA	ICGC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.1944
p.V807I	DO14159	HNSC	ICGC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.7076
p.V794F	DO228985	LICA	ICGC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.2778
p.R790Q	DO222847	MELA	ICGC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.6111
p.F800S	DO233298	NACA	ICGC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.7982
p.V794A	DO46591	OV	ICGC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.2778
p.I799L	DO47813	STAD	ICGC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.7174
p.Q814L	SIDM00130	Pancreatic Carcinoma	GDSC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.1389
p.Q814L	ACH-000138	Pancreatic Cancer	CCLE	LAPQANLTELDI	DEG_ODPH_VHL_1	0.1389
p.Q814L	CFPAC-1	pancreas	COSMIC	LAPQANLTELDI	DEG_ODPH_VHL_1	0.1389
p.G817C	ACH-000659	Lung Cancer	CCLE	LAPQANLTELDI	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13569	Cystic fibrosis transmembrane conductance regulator	DEG_ODPH_VHL_1	796:807	LAPQANLTELDI	VHL	0.5496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons