DegronMD

Uniprot ID: Q8IXR5

Source protein: Protein FAM178B

Source gene: FAM178B

Class: DEG_ODPH_VHL_1

Location: 10:23

E3 ligase: VHL

DEGRON score: 0.8652

ASA_SCORE: 92.3

COIL: 0.7274

CONS_SCORE: 0.3418

DSS_SCORE: 0.5532

HELIX: 0.1649

FCONS_SCORE: 1.0224

RIG_SCORE: 0.725

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E4Q	DO1073	BRCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.1667
p.R30H	DO222606	BTCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.1389
p.V23M	DO50090	COAD	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7208
p.V23M	DO222793	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7208
p.V23M	DO50311	ESAD	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7208
p.V23M	DO229542	UTCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7208
p.V23A	DO230334	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6936
p.V23A	DO229010	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6936
p.V23A	DO229013	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6936
p.V23A	DO229016	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6936
p.V23A	DO229003	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6936
p.V23A	DO229005	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6936
p.V23A	DO228941	LICA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6936
p.V23A	DO230550	LUSC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6936
p.R20W	DO50454	ESAD	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7523
p.R20W	DO229234	THCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7523
p.R20W	ACH-001130	Lymphoma	CCLE	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7523
p.R33M	DO233867	GACA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.0556
p.T7K	DO228929	LICA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.25
p.E14D	DO23023	LIHC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.6758
p.M11V	DO50839	LIRI	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7208
p.M11V	ACH-000985	Colon/Colorectal Cancer	CCLE	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7208
p.Q28K	DO224563	LUSC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.1944
p.E6K	DO222363	MELA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.2222
p.A11D	DO232761	PBCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.7793
p.E31G	DO229264	THCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.1111
p.T7M	DO43899	UCEC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.25
p.T7M	DO42665	UCEC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.25
p.L31M	ACH-001389	Breast Cancer	CCLE	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.1111
p.L6V	G-402	soft_tissue	COSMIC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPQLRRQDQRLHF

Degron related mutations and impact score

Drug responses associated with FAM178B mutations

All proteins holding degron of LAPQLRRQDQRLHF

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXR5	Protein FAM178B	DEG_ODPH_VHL_1	10:23	LAPQLRRQDQRLHF	VHL	0.8652	More...