DegronMD - Q8IXR5(FAM178B)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K584N	TCGA-AA-3947	COAD	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation substituting flanking lysine	0.1667
p.P574S	TCGA-DF-A2KN	UCEC	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation altering degron motif	0.5641
p.L570M	TCGA-EY-A2OP	UCEC	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation altering degron motif	0.711
p.R562G	TCGA-GS-A9TQ	DLBC	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation rewiring degron network	0.2222
p.P563L	TCGA-VQ-A8P2	STAD	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation rewiring degron network	0.25
p.E4Q	DO1073	BRCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.1667
p.R30H	DO222606	BTCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.1389
p.V23M	DO50090	COAD	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7208
p.V23M	DO222793	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7208
p.V23M	DO50311	ESAD	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7208
p.V23M	DO229542	UTCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7208
p.V23A	DO230334	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6936
p.V23A	DO229010	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6936
p.V23A	DO229013	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6936
p.V23A	DO229016	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6936
p.V23A	DO229003	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6936
p.V23A	DO229005	COCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6936
p.V23A	DO228941	LICA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6936
p.V23A	DO230550	LUSC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6936
p.R20W	DO50454	ESAD	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7523
p.R20W	DO229234	THCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7523
p.R20W	ACH-001130	Lymphoma	CCLE	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7523
p.R33M	DO233867	GACA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.0556
p.T7K	DO228929	LICA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.25
p.E14D	DO23023	LIHC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.6758
p.M11V	DO50839	LIRI	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7208
p.M11V	ACH-000985	Colon/Colorectal Cancer	CCLE	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7208
p.Q28K	DO224563	LUSC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.1944
p.E6K	DO222363	MELA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.2222
p.A11D	DO232761	PBCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation altering degron motif	0.7793
p.E31G	DO229264	THCA	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.1111
p.T7M	DO43899	UCEC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.25
p.T7M	DO42665	UCEC	ICGC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.25
p.L566V	SIDM00855	Other Sarcomas	GDSC	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation altering degron motif	0.5654
p.L566V	G-402	soft tissue	COSMIC	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation altering degron motif	0.5654
p.M561I	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation rewiring degron network	0.1944
p.M561I	ACH-002263	Esophageal Cancer	CCLE	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation rewiring degron network	0.1944
p.M561I	KYSE-220	oesophagus	COSMIC	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation rewiring degron network	0.1944
p.R567G	SIDM01617	Endometrial Carcinoma	GDSC	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation altering degron motif	0.7568
p.R567G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation altering degron motif	0.7568
p.E580K	ACH-000696	Ovarian Cancer	CCLE	LRQYLDSVP	DEG_APCC_DBOX_1	566:574	Mutation rewiring degron network	0.1667
p.L31M	ACH-001389	Breast Cancer	CCLE	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.1111
p.L6V	G-402	soft tissue	COSMIC	LAPQLRRQDQRLHF	DEG_ODPH_VHL_1	10:23	Mutation rewiring degron network	0.2222

Kaplan plot for FAM178B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM178B

UniProt ID: Q8IXR5

Entrez ID: 51252

Protein name: Protein FAM178B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM178B in