DegronMD

Uniprot ID: Q8IXR5

Source protein: Protein FAM178B

Source gene: FAM178B

Class: DEG_APCC_DBOX_1

Location: 566:574

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.531

ASA_SCORE: 68.0333

COIL: 0.4853

CONS_SCORE: 0.6301

DSS_SCORE: 0.3773

HELIX: 0.4832

FCONS_SCORE: 1.235

RIG_SCORE: 0.7224

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K584N	TCGA-AA-3947	COAD	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	0.1667
p.P574S	TCGA-DF-A2KN	UCEC	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	0.5641
p.L570M	TCGA-EY-A2OP	UCEC	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	0.711
p.R562G	TCGA-GS-A9TQ	DLBC	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	0.2222
p.P563L	TCGA-VQ-A8P2	STAD	TCGA	LRQYLDSVP	DEG_APCC_DBOX_1	0.25
p.L566V	SIDM00855	Other Sarcomas	GDSC	LRQYLDSVP	DEG_APCC_DBOX_1	0.5654
p.L566V	G-402	soft_tissue	COSMIC	LRQYLDSVP	DEG_APCC_DBOX_1	0.5654
p.M561I	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LRQYLDSVP	DEG_APCC_DBOX_1	0.1944
p.M561I	ACH-002263	Esophageal Cancer	CCLE	LRQYLDSVP	DEG_APCC_DBOX_1	0.1944
p.M561I	KYSE-220	oesophagus	COSMIC	LRQYLDSVP	DEG_APCC_DBOX_1	0.1944
p.R567G	SIDM01617	Endometrial Carcinoma	GDSC	LRQYLDSVP	DEG_APCC_DBOX_1	0.7568
p.R567G	ACH-000994	Endometrial/Uterine Cancer	CCLE	LRQYLDSVP	DEG_APCC_DBOX_1	0.7568
p.E580K	ACH-000696	Ovarian Cancer	CCLE	LRQYLDSVP	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXR5	Protein FAM178B	DEG_APCC_DBOX_1	566:574	LRQYLDSVP	APC,CDC20,FZR1	0.531	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons