DegronMD

Uniprot ID: Q6PEX7

Source protein: Testis-expressed protein 38

Source gene: TEX38

Class: DEG_ODPH_VHL_1

Location: 134:147

E3 ligase: VHL

DEGRON score: 0.818

ASA_SCORE: 85.1643

COIL: 0.9002

CONS_SCORE: 0.6427

DSS_SCORE: 0.5604

HELIX: 0.0534

FCONS_SCORE: 0.8538

RIG_SCORE: 0.6469

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S128T	DO229480	LAML	ICGC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.1667
p.P125H	DO42280	UCEC	ICGC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.0833
p.R128C	DO42608	UCEC	ICGC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.1667
p.S143F	SIDM01652	Non-Cancerous	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00187	Kidney Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00082	Melanoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00735	Small Cell Lung Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00202	Ewing's Sarcoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00965	Small Cell Lung Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM01113	Other Sarcomas	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00842	Colorectal Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00094	Kidney Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM01132	Other Solid Cancers	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00948	Burkitt's Lymphoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00379	Glioma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM00861	Ovarian Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.S143F	SIDM01111	Ewing's Sarcoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.6871
p.P157T	SIDM00596	Endometrial Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.0556
p.P157T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.0556
p.P157T	HEC-1	endometrium	COSMIC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.0556
p.L129F	SNU-175	large_intestine	COSMIC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PEX7	Testis-expressed protein 38	DEG_ODPH_VHL_1	134:147	LAPQQPQARSPFPL	VHL	0.818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPQQPQARSPFPL

Degron related mutations and impact score

Drug responses associated with TEX38 mutations

All proteins holding degron of LAPQQPQARSPFPL