DegronMD - Q6PEX7(TEX38)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L162I	TCGA-AA-A010	COAD	TCGA	LPIFQE	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.0556
p.I149N	TCGA-AP-A059	UCEC	TCGA	LPIFQE	LIG_APCC_ABBA_1	147:152	Mutation altering degron motif	0.728
p.S128T	DO229480	LAML	ICGC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation rewiring degron network	0.1667
p.P125H	DO42280	UCEC	ICGC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation rewiring degron network	0.0833
p.R128C	DO42608	UCEC	ICGC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation rewiring degron network	0.1667
p.S143F	SIDM01652	Non-Cancerous	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00187	Kidney Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00082	Melanoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00735	Small Cell Lung Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00202	Ewing's Sarcoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00965	Small Cell Lung Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM01113	Other Sarcomas	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00842	Colorectal Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00094	Kidney Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM01132	Other Solid Cancers	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00948	Burkitt's Lymphoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00379	Glioma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM00861	Ovarian Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.S143F	SIDM01111	Ewing's Sarcoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation altering degron motif	0.6871
p.P157T	SIDM00596	Endometrial Carcinoma	GDSC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation rewiring degron network	0.0556
p.P157T	SIDM00596	Endometrial Carcinoma	GDSC	LPIFQE	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.1944
p.P157T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation rewiring degron network	0.0556
p.P157T	ACH-001517	Endometrial/Uterine Cancer	CCLE	LPIFQE	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.1944
p.P157T	HEC-1	endometrium	COSMIC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation rewiring degron network	0.0556
p.P157T	HEC-1	endometrium	COSMIC	LPIFQE	LIG_APCC_ABBA_1	147:152	Mutation rewiring degron network	0.1944
p.L129F	SNU-175	large intestine	COSMIC	LAPQQPQARSPFPL	DEG_ODPH_VHL_1	134:147	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TEX38

UniProt ID: Q6PEX7

Entrez ID: 374973

Protein name: Testis-expressed protein 38 (ATPAF1 antisense RNA 1) (ATPAF1 antisense gene protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TEX38 in