DegronMD

Uniprot ID: P48382

Source protein: DNA-binding protein RFX5

Source gene: RFX5

Class: DEG_ODPH_VHL_1

Location: 351:362

E3 ligase: VHL

DEGRON score: 0.8518

ASA_SCORE: 72.8083

COIL: 0.7299

CONS_SCORE: 0.5754

DSS_SCORE: 0.1908

HELIX: 0.0308

FCONS_SCORE: 1.0752

RIG_SCORE: 0.7225

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L351V	TCGA-63-A5MT	LUSC	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.6765
p.L351V	DO219163	LUSC	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.6765
p.P366T	TCGA-A8-A09Z	BRCA	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.2222
p.P366T	DO5521	BRCA	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.2222
p.S356Y	TCGA-DU-6392	LGG	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.712
p.S356Y	DO22237	LGG	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.712
p.L355I	TCGA-FD-A3SP	BLCA	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.6063
p.L355I	DO594	BLCA	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.6063
p.S347Y	TCGA-VQ-A8P2	STAD	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.6667
p.S347Y	DO51761	STAD	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.6667
p.I350F	DO228470	LICA	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.3056
p.P345S	DO222731	MELA	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.1667
p.S368F	SIDM01228	Melanoma	GDSC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.1667
p.S368F	ACH-000931	Skin Cancer	CCLE	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.1667
p.S368F	ACH-001024	Skin Cancer	CCLE	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.1667
p.S368F	CHL-1	skin	COSMIC	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.1667
p.G372R	ACH-001786	Colon/Colorectal Cancer	CCLE	LAPRLSSGALKV	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48382	DNA-binding protein RFX5	DEG_ODPH_VHL_1	351:362	LAPRLSSGALKV	VHL	0.8518	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons