DegronMD - P48382(RFX5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L351V	TCGA-63-A5MT	LUSC	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation altering degron motif	0.6765
p.L351V	DO219163	LUSC	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation altering degron motif	0.6765
p.S162C	TCGA-A2-A3Y0	BRCA	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.25
p.S162C	DO44273	BRCA	ICGC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.25
p.P366T	TCGA-A8-A09Z	BRCA	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.2222
p.P366T	DO5521	BRCA	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.2222
p.D179N	TCGA-AO-A0JC	BRCA	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1667
p.D179N	DO5277	BRCA	ICGC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1667
p.K181N	TCGA-D3-A2JP	SKCM	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation substituting flanking lysine	0.2222
p.K181N	DO47407	SKCM	ICGC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation substituting flanking lysine	0.2222
p.S356Y	TCGA-DU-6392	LGG	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation altering degron motif	0.712
p.S356Y	DO22237	LGG	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation altering degron motif	0.712
p.G155S	TCGA-DY-A0XA	READ	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.G155S	DO37026	READ	ICGC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.0556
p.L355I	TCGA-FD-A3SP	BLCA	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation altering degron motif	0.6063
p.L355I	DO594	BLCA	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation altering degron motif	0.6063
p.M172V	TCGA-L5-A4OT	ESCA	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6097
p.M172V	SIDM00957	Colorectal Carcinoma	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6097
p.M172V	SIDM00653	Small Cell Lung Carcinoma	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6097
p.M172V	ACH-000350	Colon/Colorectal Cancer	CCLE	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6097
p.M172V	ACH-000514	Lung Cancer	CCLE	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6097
p.M172V	NCI-H1092	lung	COSMIC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6097
p.M172V	COLO-678	large intestine	COSMIC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.6097
p.S347Y	TCGA-VQ-A8P2	STAD	TCGA	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation blocking phosphorylation signal	0.6667
p.S347Y	DO51761	STAD	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation blocking phosphorylation signal	0.6667
p.I350F	DO228470	LICA	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.3056
p.P345S	DO222731	MELA	ICGC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.1667
p.C160R	SIDM01090	Colorectal Carcinoma	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1944
p.C160R	ACH-000943	Colon/Colorectal Cancer	CCLE	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1944
p.C160R	RKO	large intestine	COSMIC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation rewiring degron network	0.1944
p.R166S	SIDM00006	Other Solid Cancers	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.7427
p.R166S	ACH-001552	Skin Cancer	CCLE	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.7427
p.R166S	MCC26	skin	COSMIC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation altering degron motif	0.7427
p.S368F	SIDM01228	Melanoma	GDSC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.1667
p.S368F	ACH-000931	Skin Cancer	CCLE	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.1667
p.S368F	ACH-001024	Skin Cancer	CCLE	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.1667
p.S368F	CHL-1	skin	COSMIC	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.1667
p.S183P	SIDM01502	Endometrial Carcinoma	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	165:173	Mutation blocking phosphorylation signal	0.5
p.G372R	ACH-001786	Colon/Colorectal Cancer	CCLE	LAPRLSSGALKV	DEG_ODPH_VHL_1	351:362	Mutation rewiring degron network	0.0556

Kaplan plot for RFX5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFX5

UniProt ID: P48382

Entrez ID: 5993

Protein name: DNA-binding protein RFX5 (Regulatory factor X 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFX5 in