DegronMD

Uniprot ID: P48382

Source protein: DNA-binding protein RFX5

Source gene: RFX5

Class: DEG_APCC_DBOX_1

Location: 165:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9161

ASA_SCORE: 75.5111

COIL: 0.6509

CONS_SCORE: 0.7616

DSS_SCORE: 0.4115

HELIX: 0.0084

FCONS_SCORE: 0.9796

RIG_SCORE: 0.753

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S162C	TCGA-A2-A3Y0	BRCA	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	0.25
p.S162C	DO44273	BRCA	ICGC	RRKTLVSMP	DEG_APCC_DBOX_1	0.25
p.D179N	TCGA-AO-A0JC	BRCA	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	0.1667
p.D179N	DO5277	BRCA	ICGC	RRKTLVSMP	DEG_APCC_DBOX_1	0.1667
p.K181N	TCGA-D3-A2JP	SKCM	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	0.2222
p.K181N	DO47407	SKCM	ICGC	RRKTLVSMP	DEG_APCC_DBOX_1	0.2222
p.G155S	TCGA-DY-A0XA	READ	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	0.0556
p.G155S	DO37026	READ	ICGC	RRKTLVSMP	DEG_APCC_DBOX_1	0.0556
p.M172V	TCGA-L5-A4OT	ESCA	TCGA	RRKTLVSMP	DEG_APCC_DBOX_1	0.6097
p.M172V	SIDM00957	Colorectal Carcinoma	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	0.6097
p.M172V	SIDM00653	Small Cell Lung Carcinoma	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	0.6097
p.M172V	ACH-000350	Colon/Colorectal Cancer	CCLE	RRKTLVSMP	DEG_APCC_DBOX_1	0.6097
p.M172V	ACH-000514	Lung Cancer	CCLE	RRKTLVSMP	DEG_APCC_DBOX_1	0.6097
p.M172V	NCI-H1092	lung	COSMIC	RRKTLVSMP	DEG_APCC_DBOX_1	0.6097
p.M172V	COLO-678	large_intestine	COSMIC	RRKTLVSMP	DEG_APCC_DBOX_1	0.6097
p.C160R	SIDM01090	Colorectal Carcinoma	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	0.1944
p.C160R	ACH-000943	Colon/Colorectal Cancer	CCLE	RRKTLVSMP	DEG_APCC_DBOX_1	0.1944
p.C160R	RKO	large_intestine	COSMIC	RRKTLVSMP	DEG_APCC_DBOX_1	0.1944
p.R166S	SIDM00006	Other Solid Cancers	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	0.7427
p.R166S	ACH-001552	Skin Cancer	CCLE	RRKTLVSMP	DEG_APCC_DBOX_1	0.7427
p.R166S	MCC26	skin	COSMIC	RRKTLVSMP	DEG_APCC_DBOX_1	0.7427
p.S183P	SIDM01502	Endometrial Carcinoma	GDSC	RRKTLVSMP	DEG_APCC_DBOX_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48382	DNA-binding protein RFX5	DEG_APCC_DBOX_1	165:173	RRKTLVSMP	APC,CDC20,FZR1	0.9161	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons