DegronMD

Uniprot ID: O75643

Source protein: U5 small nuclear ribonucleoprotein 200 kDa helicase

Source gene: SNRNP200

Class: DEG_ODPH_VHL_1

Location: 403:416

E3 ligase: VHL

DEGRON score: 0.8946

ASA_SCORE: 75.1857

COIL: 0.5837

CONS_SCORE: 0.315

DSS_SCORE: 0.3526

HELIX: 0.3082

FCONS_SCORE: 1.1194

RIG_SCORE: 0.8197

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R406L	TCGA-55-8301	LUAD	TCGA	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.7316
p.R406L	DO24682	LUAD	ICGC	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.7316
p.E401K	TCGA-86-8673	LUAD	TCGA	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.2778
p.E401K	DO26260	LUAD	ICGC	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.2778
p.E412D	TCGA-DQ-5629	HNSC	TCGA	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.5647
p.E412D	DO15270	HNSC	ICGC	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.5647
p.R406Q	SIDM00839	Colorectal Carcinoma	GDSC	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.6218
p.R406Q	ACH-000950	Colon/Colorectal Cancer	CCLE	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.6218
p.R406Q	LoVo	large_intestine	COSMIC	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.6218
p.Q398R	ACH-000593	Bladder Cancer	CCLE	LAPRQVLDLEDLVF	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75643	U5 small nuclear ribonucleoprotein 200 kDa helicase	DEG_ODPH_VHL_1	403:416	LAPRQVLDLEDLVF	VHL	0.8946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons