DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_ODPH_VHL_1

Location: 1445:1457

E3 ligase: VHL

DEGRON score: 0.6413

ASA_SCORE: 95.2154

COIL: 0.8204

CONS_SCORE: 0

DSS_SCORE: 0.426

HELIX: 0.0238

FCONS_SCORE: 0

RIG_SCORE: 0.7966

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1436Y	TCGA-19-5956	GBM	TCGA	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.0833
p.S1436Y	DO13863	GBM	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.0833
p.T1466R	TCGA-66-2785	LUSC	TCGA	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.0833
p.T1466R	DO26520	LUSC	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.0833
p.T1466I	TCGA-A5-A0G2	UCEC	TCGA	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.0833
p.T1466I	DO41235	UCEC	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.0833
p.A1458T	TCGA-A5-A2K5	UCEC	TCGA	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.3056
p.A1458T	DO41379	UCEC	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.3056
p.Q1450K	TCGA-AO-A124	BRCA	TCGA	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.5833
p.Q1450K	DO1287	BRCA	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.5833
p.D1437N	TCGA-BQ-5878	KIRP	TCGA	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.1111
p.D1437N	DO20823	KIRP	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.1111
p.L1443M	TCGA-G4-6309	COAD	TCGA	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.2778
p.L1443M	DO7810	COAD	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.2778
p.P1442S	TCGA-WY-A859	LGG	TCGA	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.25
p.P1442S	DO219859	LGG	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.25
p.A1458E	DO228971	LICA	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.3056
p.T1459K	DO228986	LICA	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.2778
p.L1445F	DO220890	MELA	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.6981
p.G1440E	DO218863	SKCA	ICGC	LAPSEQTTITLPM	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_ODPH_VHL_1	1445:1457	LAPSEQTTITLPM	VHL	0.6413	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons