DegronMD

Uniprot ID: Q5VWG9

Source protein: Transcription initiation factor TFIID subunit 3

Source gene: TAF3

Class: DEG_ODPH_VHL_1

Location: 752:765

E3 ligase: VHL

DEGRON score: 0.8206

ASA_SCORE: 90.6143

COIL: 0.9072

CONS_SCORE: 0.4055

DSS_SCORE: 0.3704

HELIX: 0.0314

FCONS_SCORE: 1.1447

RIG_SCORE: 0.7817

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K744N	TCGA-44-A4SS	LUAD	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.2222
p.K744N	DO24227	LUAD	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.2222
p.A751T	TCGA-5U-AB0D	THYM	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751T	ACH-001786	Colon/Colorectal Cancer	CCLE	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751D	TCGA-AP-A1DV	UCEC	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751D	DO43186	UCEC	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.P756L	TCGA-WE-A8K4	SKCM	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.6471
p.P756L	DO51281	SKCM	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.6471
p.Q769K	TCGA-XP-A8T8	ESCA	TCGA	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.2222
p.A751V	DO229003	COCA	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	DO230659	LAML	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	DO231140	LAML	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00958	Chronic Myelogenous Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00232	Kidney Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00781	Colorectal Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00590	Oral Cavity Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01154	T-Lymphoblastic Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00040	Gastric Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00282	Colorectal Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00556	Neuroblastoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01172	Acute Myeloid Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00587	Biliary Tract Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00487	Colorectal Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00251	Gastric Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01210	Glioblastoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00368	Small Cell Lung Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00289	B-Lymphoblastic Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00316	Glioblastoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01612	Endometrial Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01320	Pancreatic Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01611	Endometrial Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01776	Plasma Cell Myeloma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01471	Chronic Myelogenous Leukemia	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM00780	Colorectal Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751V	SIDM01413	Oral Cavity Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.G766V	DO229031	LICA	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.A751S	DO229036	LICA	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.3056
p.V757D	DO228338	MALY	ICGC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.6674
p.V757D	SIDM00948	Burkitt's Lymphoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.6674
p.V757D	ACH-002232	Lymphoma	CCLE	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.6674
p.V757D	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.6674
p.P749L	SIDM01779	Gastric Carcinoma	GDSC	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.25
p.P749L	ACH-000761	Gastric Cancer	CCLE	LAPSPVIPRLTLRV	DEG_ODPH_VHL_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPSPVIPRLTLRV

Degron related mutations and impact score

Drug responses associated with TAF3 mutations

All proteins holding degron of LAPSPVIPRLTLRV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VWG9	Transcription initiation factor TFIID subunit 3	DEG_ODPH_VHL_1	752:765	LAPSPVIPRLTLRV	VHL	0.8206	More...