DegronMD

Uniprot ID: Q99814

Source protein: Endothelial PAS domain-containing protein 1

Source gene: EPAS1

Class: DEG_ODPH_VHL_1

Location: 403:416

E3 ligase: VHL

DEGRON score: 0.999

ASA_SCORE: 67.8643

COIL: 0.7065

CONS_SCORE: 0.7551

DSS_SCORE: 0.4672

HELIX: 0.1445

FCONS_SCORE: 1.1273

RIG_SCORE: 0.7695

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A404T	TCGA-2G-AALW	TGCT	TCGA	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.7139
p.P407T	TCGA-BA-5555	HNSC	TCGA	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.5919
p.P407T	DO14220	HNSC	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.5919
p.E398K	DO225366	BRCA	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.1944
p.E396D	DO229041	LICA	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.1389
p.A410T	DO231691	LINC	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.6028
p.G408E	DO220896	MELA	ICGC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.6087
p.L403R	SIDM00417	Plasma Cell Myeloma	GDSC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.8428
p.L403R	ACH-000626	Myeloma	CCLE	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.8428
p.L403R	U-266	haematopoietic_and_lymphoid_tissue	COSMIC	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.8428
p.F421L	ACH-001536	Bile Duct Cancer	CCLE	LAPTPGDAIISLDF	DEG_ODPH_VHL_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99814	Endothelial PAS domain-containing protein 1	DEG_ODPH_VHL_1	403:416	LAPTPGDAIISLDF	VHL	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons