DegronMD

Uniprot ID: Q99814

Source protein: Endothelial PAS domain-containing protein 1

Source gene: EPAS1

Class: DEG_ODPH_VHL_1

Location: 574:585

E3 ligase: VHL

DEGRON score: 0.9871

ASA_SCORE: 86

COIL: 0.8362

CONS_SCORE: 0.746

DSS_SCORE: 0.3708

HELIX: 0.1441

FCONS_SCORE: 1.0515

RIG_SCORE: 0.7303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S594I	TCGA-VQ-A91D	STAD	TCGA	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.0833
p.S594I	DO51783	STAD	ICGC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.0833
p.P579T	TCGA-VQ-AA69	STAD	TCGA	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.5919
p.P579T	DO222385	STAD	ICGC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.5919
p.E593K	DO234350	ESAD	ICGC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.1111
p.L584I	SIDM00282	Colorectal Carcinoma	GDSC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.6063
p.L584I	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.6063
p.L584I	CW-2	large_intestine	COSMIC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.6063
p.F564L	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.0556
p.F564L	ACH-000309	Lung Cancer	CCLE	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.0556
p.F564L	SK-LU-1	lung	COSMIC	LAPVAPHSPFLL	DEG_ODPH_VHL_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99814	Endothelial PAS domain-containing protein 1	DEG_ODPH_VHL_1	574:585	LAPVAPHSPFLL	VHL	0.9871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons