DegronMD

Uniprot ID: Q99814

Source protein: Endothelial PAS domain-containing protein 1

Source gene: EPAS1

Class: DEG_ODPH_VHL_1

Location: 529:542

E3 ligase: VHL

DEGRON score: 0.9926

ASA_SCORE: 69.4071

COIL: 0.7787

CONS_SCORE: 0.7492

DSS_SCORE: 0.4453

HELIX: 0.1587

FCONS_SCORE: 1.0227

RIG_SCORE: 0.7733

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C546F	TCGA-53-7624	LUAD	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.2222
p.C546F	DO25058	LUAD	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.2222
p.T519M	TCGA-AN-A0AK	BRCA	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.0556
p.T519M	DO1608	BRCA	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.0556
p.R550W	TCGA-AX-A3FT	UCEC	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1111
p.R550W	TCGA-BR-8361	STAD	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1111
p.R550W	DO48032	STAD	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1111
p.R550W	DO40801	UCEC	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1111
p.R550W	SIDM01619	Endometrial Carcinoma	GDSC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1111
p.R550W	ACH-000984	Endometrial/Uterine Cancer	CCLE	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1111
p.E538K	TCGA-DA-A1HY	SKCM	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.591
p.E538K	DO37409	SKCM	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.591
p.E538K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.591
p.E538K	ACH-000916	Lung Cancer	CCLE	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.591
p.E538K	NCI-H1573	lung	COSMIC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.591
p.P531L	TCGA-QR-A7IN	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.7582
p.P531L	TCGA-QT-A7U0	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.7582
p.P531S	TCGA-QT-A5XL	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.6752
p.Y532C	TCGA-RW-A68D	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.5976
p.Y532C	TCGA-SR-A6MV	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.5976
p.P531A	TCGA-S7-A7X0	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.7503
p.A530V	TCGA-WB-A814	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.6936
p.A530V	TCGA-WB-A821	PCPG	TCGA	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.6936
p.T528I	DO222427	BTCA	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.75
p.L542R	DO23256	LINC	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.8428
p.N522S	DO52365	LUSC	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1389
p.N522S	SIDM01079	Melanoma	GDSC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1389
p.N522S	ACH-000441	Skin Cancer	CCLE	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1389
p.N522S	SH-4	skin	COSMIC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.1389
p.D520N	DO222753	MELA	ICGC	LAPYIPMDGEDFQL	DEG_ODPH_VHL_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPYIPMDGEDFQL

Degron related mutations and impact score

Drug responses associated with EPAS1 mutations

All proteins holding degron of LAPYIPMDGEDFQL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99814	Endothelial PAS domain-containing protein 1	DEG_ODPH_VHL_1	529:542	LAPYIPMDGEDFQL	VHL	0.9926	More...