DegronMD

Uniprot ID: Q12888

Source protein: TP53-binding protein 1

Source gene: TP53BP1

Class: DEG_SCF_FBW7_1

Location: 331:338

E3 ligase: FBXW7

DEGRON score: 0.9996

ASA_SCORE: 80.275

COIL: 0.8638

CONS_SCORE: 0.4384

DSS_SCORE: 0.426

HELIX: 0.0611

FCONS_SCORE: 1.2698

RIG_SCORE: 0.7211

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P340S	TCGA-90-A4ED	LUSC	TCGA	LASTPATT	DEG_SCF_FBW7_1	0.2778
p.P340S	TCGA-RP-A693	SKCM	TCGA	LASTPATT	DEG_SCF_FBW7_1	0.2778
p.S325F	TCGA-C5-A1MH	CESC	TCGA	LASTPATT	DEG_SCF_FBW7_1	0.1667
p.R348K	DO3822	BRCA	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.0556
p.S345C	DO51612	CESC	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.1389
p.A336D	DO229006	LICA	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.6682
p.P335T	DO229008	LICA	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.7031
p.P335S	DO45482	LUSC	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.6752
p.P335S	DO51268	SKCM	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.6752
p.L339V	DO52144	PAEN	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.3056
p.G327V	DO229523	PRAD	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.2222
p.S323L	DO219871	SKCA	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.5556
p.G328W	DO229250	THCA	ICGC	LASTPATT	DEG_SCF_FBW7_1	0.25
p.S335C	SIDM00568	Gastric Carcinoma	GDSC	LASTPATT	DEG_SCF_FBW7_1	0.7541
p.S335C	SIDM00817	Kidney Carcinoma	GDSC	LASTPATT	DEG_SCF_FBW7_1	0.7541
p.S335C	SIDM01471	Chronic Myelogenous Leukemia	GDSC	LASTPATT	DEG_SCF_FBW7_1	0.7541
p.S335C	ACH-000247	Gastric Cancer	CCLE	LASTPATT	DEG_SCF_FBW7_1	0.7541
p.S335C	ACH-000604	Leukemia	CCLE	LASTPATT	DEG_SCF_FBW7_1	0.7541
p.S335C	OCUM-1	stomach	COSMIC	LASTPATT	DEG_SCF_FBW7_1	0.7541
p.D322G	SIDM01019	Acute Myeloid Leukemia	GDSC	LASTPATT	DEG_SCF_FBW7_1	0.0833
p.D322G	ACH-002258	Leukemia	CCLE	LASTPATT	DEG_SCF_FBW7_1	0.0833
p.D322G	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	LASTPATT	DEG_SCF_FBW7_1	0.0833
p.S330C	OCUM-1	stomach	COSMIC	LASTPATT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_SCF_FBW7_1	331:338	LASTPATT	FBXW7	0.9996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons