DegronMD

Uniprot ID: Q9H161

Source protein: Homeobox protein aristaless-like 4

Source gene: ALX4

Class: DEG_SCF_FBW7_1

Location: 73:79

E3 ligase: FBXW7

DEGRON score: 0.9979

ASA_SCORE: 71.1857

COIL: 0.8001

CONS_SCORE: 0.5773

DSS_SCORE: 0.6436

HELIX: 0.0804

FCONS_SCORE: 1.0471

RIG_SCORE: 0.6814

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G85D	TCGA-AJ-A3EL	UCEC	TCGA	LATPLES	DEG_SCF_FBW7_1	0.1667
p.G85D	DO41542	UCEC	ICGC	LATPLES	DEG_SCF_FBW7_1	0.1667
p.R63Q	TCGA-AY-6197	COAD	TCGA	LATPLES	DEG_SCF_FBW7_1	0.0556
p.R63Q	DO9956	COAD	ICGC	LATPLES	DEG_SCF_FBW7_1	0.0556
p.G69E	TCGA-CI-6624	READ	TCGA	LATPLES	DEG_SCF_FBW7_1	0.2222
p.G69E	DO37130	READ	ICGC	LATPLES	DEG_SCF_FBW7_1	0.2222
p.R63W	DO233109	GACA	ICGC	LATPLES	DEG_SCF_FBW7_1	0.0556
p.R84W	DO233636	GACA	ICGC	LATPLES	DEG_SCF_FBW7_1	0.1944
p.P76T	DO229353	LAML	ICGC	LATPLES	DEG_SCF_FBW7_1	0.7031
p.P76T	SIDM00233	T-Lymphoblastic Leukemia	GDSC	LATPLES	DEG_SCF_FBW7_1	0.7031
p.A68D	DO38404	STAD	ICGC	LATPLES	DEG_SCF_FBW7_1	0.1944
p.D72E	SIDM00760	Small Cell Lung Carcinoma	GDSC	LATPLES	DEG_SCF_FBW7_1	0.3056
p.D72E	ACH-000729	Lung Cancer	CCLE	LATPLES	DEG_SCF_FBW7_1	0.3056
p.G85S	SIDM01590	Breast Carcinoma	GDSC	LATPLES	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H161	Homeobox protein aristaless-like 4	DEG_SCF_FBW7_1	73:79	LATPLES	FBXW7	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons