DegronMD

Uniprot ID: Q96PQ1

Source protein: Sialic acid-binding Ig-like lectin 12

Source gene: SIGLEC12

Class: DEG_SCF_FBW7_2

Location: 553:559

E3 ligase: FBXW7

DEGRON score: 0.7802

ASA_SCORE: 93.7714

COIL: 0.9543

CONS_SCORE: 0.2328

DSS_SCORE: 0.7607

HELIX: 0.0284

FCONS_SCORE: 0.7063

RIG_SCORE: 0.5636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A552T	TCGA-59-A5PD	OV	TCGA	LATPSPE	DEG_SCF_FBW7_2	0.3056
p.Q564H	TCGA-66-2763	LUSC	TCGA	LATPSPE	DEG_SCF_FBW7_2	0.1944
p.Q564K	TCGA-99-AA5R	LUAD	TCGA	LATPSPE	DEG_SCF_FBW7_2	0.1944
p.E560K	TCGA-EE-A2GC	SKCM	TCGA	LATPSPE	DEG_SCF_FBW7_2	0.3056
p.H548Q	SIDM00186	Kidney Carcinoma	GDSC	LATPSPE	DEG_SCF_FBW7_2	0.1944
p.H548Q	SIDM01651	Non-Cancerous	GDSC	LATPSPE	DEG_SCF_FBW7_2	0.1944
p.H548Q	ACH-002353	Non-Cancerous	CCLE	LATPSPE	DEG_SCF_FBW7_2	0.1944
p.P545H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LATPSPE	DEG_SCF_FBW7_2	0.1111
p.P545H	ACH-000929	Lung Cancer	CCLE	LATPSPE	DEG_SCF_FBW7_2	0.1111
p.P545H	NCI-H2110	lung	COSMIC	LATPSPE	DEG_SCF_FBW7_2	0.1111
p.P545T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LATPSPE	DEG_SCF_FBW7_2	0.1111
p.P545T	ACH-000929	Lung Cancer	CCLE	LATPSPE	DEG_SCF_FBW7_2	0.1111
p.P545T	NCI-H2110	lung	COSMIC	LATPSPE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PQ1	Sialic acid-binding Ig-like lectin 12	DEG_SCF_FBW7_2	553:559	LATPSPE	FBXW7	0.7802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons