DegronMD

Uniprot ID: Q9UHR5

Source protein: SAP30-binding protein

Source gene: SAP30BP

Class: LIG_APCC_ABBA_1

Location: 11:16

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9851

ASA_SCORE: 61.3833

COIL: 0.4858

CONS_SCORE: 0.4234

DSS_SCORE: 0.4875

HELIX: 0.357

FCONS_SCORE: 1.2318

RIG_SCORE: 0.7614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E21Q	TCGA-05-4424	LUAD	TCGA	LAVYAE	LIG_APCC_ABBA_1	0.1944
p.E21Q	DO23672	LUAD	ICGC	LAVYAE	LIG_APCC_ABBA_1	0.1944
p.E25Q	TCGA-49-6745	LUAD	TCGA	LAVYAE	LIG_APCC_ABBA_1	0.0833
p.E25Q	DO23862	LUAD	ICGC	LAVYAE	LIG_APCC_ABBA_1	0.0833
p.G3W	TCGA-BF-A1Q0	SKCM	TCGA	LAVYAE	LIG_APCC_ABBA_1	0.1111
p.G3W	DO47374	SKCM	ICGC	LAVYAE	LIG_APCC_ABBA_1	0.1111
p.L11F	DO222650	BTCA	ICGC	LAVYAE	LIG_APCC_ABBA_1	0.587
p.G3R	SIDM00789	Colorectal Carcinoma	GDSC	LAVYAE	LIG_APCC_ABBA_1	0.1111
p.G3R	ACH-000997	Colon/Colorectal Cancer	CCLE	LAVYAE	LIG_APCC_ABBA_1	0.1111
p.G3R	ACH-001061	Colon/Colorectal Cancer	CCLE	LAVYAE	LIG_APCC_ABBA_1	0.1111
p.G3R	HCT-15	large_intestine	COSMIC	LAVYAE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHR5	SAP30-binding protein	LIG_APCC_ABBA_1	11:16	LAVYAE	APC,CDC20,FZR1	0.9851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons