DegronMD

Uniprot ID: P37198

Source protein: Nuclear pore glycoprotein p62

Source gene: NUP62

Class: DEG_SCF_FBW7_1

Location: 239:245

E3 ligase: FBXW7

DEGRON score: 0.7541

ASA_SCORE: 84.2143

COIL: 0.8846

CONS_SCORE: 0.4945

DSS_SCORE: 0.3881

HELIX: 0.0297

FCONS_SCORE: 1.2271

RIG_SCORE: 0.8012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T244I	TCGA-AC-A3W5	BRCA	TCGA	LCTPVTT	DEG_SCF_FBW7_1	0.5966
p.T244I	DO49024	BRCA	ICGC	LCTPVTT	DEG_SCF_FBW7_1	0.5966
p.P249S	TCGA-CW-5587	KIRC	TCGA	LCTPVTT	DEG_SCF_FBW7_1	0.2222
p.P249S	DO19430	KIRC	ICGC	LCTPVTT	DEG_SCF_FBW7_1	0.2222
p.T234N	DO229031	LICA	ICGC	LCTPVTT	DEG_SCF_FBW7_1	0.1944
p.T253A	DO229253	THCA	ICGC	LCTPVTT	DEG_SCF_FBW7_1	0.1111
p.A251T	SIDM02023	Pancreatic Carcinoma	GDSC	LCTPVTT	DEG_SCF_FBW7_1	0.1667
p.C240R	SIDM01162	Kidney Carcinoma	GDSC	LCTPVTT	DEG_SCF_FBW7_1	0.719
p.C240R	ACH-001398	Kidney Cancer	CCLE	LCTPVTT	DEG_SCF_FBW7_1	0.719
p.C240R	SW156	kidney	COSMIC	LCTPVTT	DEG_SCF_FBW7_1	0.719
p.T245I	SIDM00373	Endometrial Carcinoma	GDSC	LCTPVTT	DEG_SCF_FBW7_1	0.7078
p.T245I	ACH-000974	Endometrial/Uterine Cancer	CCLE	LCTPVTT	DEG_SCF_FBW7_1	0.7078
p.T245I	SNG-M	endometrium	COSMIC	LCTPVTT	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P37198	Nuclear pore glycoprotein p62	DEG_SCF_FBW7_1	239:245	LCTPVTT	FBXW7	0.7541	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons