DegronMD

Uniprot ID: Q658Y4

Source protein: Protein FAM91A1

Source gene: FAM91A1

Class: LIG_APCC_ABBA_1

Location: 783:788

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.517

ASA_SCORE: 76.4

COIL: 0.7848

CONS_SCORE: 0.2611

DSS_SCORE: 0.2073

HELIX: 0.1465

FCONS_SCORE: 0.8399

RIG_SCORE: 0.7858

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q797R	TCGA-05-5423	LUAD	TCGA	LDIHTE	LIG_APCC_ABBA_1	0.0833
p.Q797R	DO26132	LUAD	ICGC	LDIHTE	LIG_APCC_ABBA_1	0.0833
p.A780P	TCGA-86-8074	LUAD	TCGA	LDIHTE	LIG_APCC_ABBA_1	0.25
p.A780P	DO25330	LUAD	ICGC	LDIHTE	LIG_APCC_ABBA_1	0.25
p.Q777H	TCGA-A5-A0G2	UCEC	TCGA	LDIHTE	LIG_APCC_ABBA_1	0.1667
p.Q777H	DO41235	UCEC	ICGC	LDIHTE	LIG_APCC_ABBA_1	0.1667
p.L795I	TCGA-BR-4201	STAD	TCGA	LDIHTE	LIG_APCC_ABBA_1	0.1389
p.L795I	DO38707	STAD	ICGC	LDIHTE	LIG_APCC_ABBA_1	0.1389
p.P789S	TCGA-D1-A176	UCEC	TCGA	LDIHTE	LIG_APCC_ABBA_1	0.3056
p.P789S	DO43947	UCEC	ICGC	LDIHTE	LIG_APCC_ABBA_1	0.3056
p.S796L	TCGA-IR-A3LH	CESC	TCGA	LDIHTE	LIG_APCC_ABBA_1	0.1111
p.S796L	DO44381	CESC	ICGC	LDIHTE	LIG_APCC_ABBA_1	0.1111
p.K782R	DO49703	LIHC	ICGC	LDIHTE	LIG_APCC_ABBA_1	0.3056
p.K780N	DO47769	STAD	ICGC	LDIHTE	LIG_APCC_ABBA_1	0.25
p.W786L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	LDIHTE	LIG_APCC_ABBA_1	0.7015
p.W786L	NCI-H1435	lung	COSMIC	LDIHTE	LIG_APCC_ABBA_1	0.7015

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q658Y4	Protein FAM91A1	LIG_APCC_ABBA_1	783:788	LDIHTE	APC,CDC20,FZR1	0.517	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons