DegronMD - Q658Y4(FAM91A1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q797R	TCGA-05-5423	LUAD	TCGA	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.0833
p.Q797R	DO26132	LUAD	ICGC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.0833
p.S316F	TCGA-64-1677	LUAD	TCGA	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.9093
p.S316F	TCGA-BF-AAP2	SKCM	TCGA	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.9093
p.S316F	DO23996	LUAD	ICGC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.9093
p.S316F	DO219466	SKCM	ICGC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.9093
p.A780P	TCGA-86-8074	LUAD	TCGA	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.25
p.A780P	DO25330	LUAD	ICGC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.25
p.Q777H	TCGA-A5-A0G2	UCEC	TCGA	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.1667
p.Q777H	DO41235	UCEC	ICGC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.1667
p.L795I	TCGA-BR-4201	STAD	TCGA	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.1389
p.L795I	DO38707	STAD	ICGC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.1389
p.P789S	TCGA-D1-A176	UCEC	TCGA	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.3056
p.P789S	DO43947	UCEC	ICGC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.3056
p.V317I	TCGA-D3-A1QB	SKCM	TCGA	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.5965
p.V317I	DO222492	COCA	ICGC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.5965
p.V317I	DO47573	SKCM	ICGC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.5965
p.S796L	TCGA-IR-A3LH	CESC	TCGA	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.1111
p.S796L	DO44381	CESC	ICGC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.1111
p.S322N	TCGA-WS-AB45	COAD	TCGA	SSWKNVPSV	DEG_COP1_1	309:317	Mutation blocking phosphorylation signal	0.6389
p.S322N	DO51734	COAD	ICGC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation blocking phosphorylation signal	0.6389
p.Q306E	DO224765	BRCA	ICGC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation rewiring degron network	0.25
p.Q306K	DO229336	BTCA	ICGC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation rewiring degron network	0.25
p.V314F	DO229035	LICA	ICGC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.7068
p.K782R	DO49703	LIHC	ICGC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.3056
p.K780N	DO47769	STAD	ICGC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation rewiring degron network	0.25
p.W786L	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation altering degron motif	0.7015
p.W786L	NCI-H1435	lung	COSMIC	LDIHTE	LIG_APCC_ABBA_1	783:788	Mutation altering degron motif	0.7015
p.K312N	SIDM01611	Endometrial Carcinoma	GDSC	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.5806
p.K312N	ACH-000996	Endometrial/Uterine Cancer	CCLE	SSWKNVPSV	DEG_COP1_1	309:317	Mutation altering degron motif	0.5806

Kaplan plot for FAM91A1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM91A1

UniProt ID: Q658Y4

Entrez ID: 157769

Protein name: Protein FAM91A1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM91A1 in