DegronMD

Uniprot ID: Q658Y4

Source protein: Protein FAM91A1

Source gene: FAM91A1

Class: DEG_COP1_1

Location: 309:317

E3 ligase: COP1

DEGRON score: 0.5886

ASA_SCORE: 68.0333

COIL: 0.6911

CONS_SCORE: 0.2899

DSS_SCORE: 0.3016

HELIX: 0.2712

FCONS_SCORE: 0.9844

RIG_SCORE: 0.7721

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S316F	TCGA-64-1677	LUAD	TCGA	SSWKNVPSV	DEG_COP1_1	0.9093
p.S316F	TCGA-BF-AAP2	SKCM	TCGA	SSWKNVPSV	DEG_COP1_1	0.9093
p.S316F	DO23996	LUAD	ICGC	SSWKNVPSV	DEG_COP1_1	0.9093
p.S316F	DO219466	SKCM	ICGC	SSWKNVPSV	DEG_COP1_1	0.9093
p.V317I	TCGA-D3-A1QB	SKCM	TCGA	SSWKNVPSV	DEG_COP1_1	0.5965
p.V317I	DO222492	COCA	ICGC	SSWKNVPSV	DEG_COP1_1	0.5965
p.V317I	DO47573	SKCM	ICGC	SSWKNVPSV	DEG_COP1_1	0.5965
p.S322N	TCGA-WS-AB45	COAD	TCGA	SSWKNVPSV	DEG_COP1_1	0.6389
p.S322N	DO51734	COAD	ICGC	SSWKNVPSV	DEG_COP1_1	0.6389
p.Q306E	DO224765	BRCA	ICGC	SSWKNVPSV	DEG_COP1_1	0.25
p.Q306K	DO229336	BTCA	ICGC	SSWKNVPSV	DEG_COP1_1	0.25
p.V314F	DO229035	LICA	ICGC	SSWKNVPSV	DEG_COP1_1	0.7068
p.K312N	SIDM01611	Endometrial Carcinoma	GDSC	SSWKNVPSV	DEG_COP1_1	0.5806
p.K312N	ACH-000996	Endometrial/Uterine Cancer	CCLE	SSWKNVPSV	DEG_COP1_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q658Y4	Protein FAM91A1	DEG_COP1_1	309:317	SSWKNVPSV	COP1	0.5886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons