DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: LIG_APCC_ABBA_1

Location: 813:818

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9214

ASA_SCORE: 80.25

COIL: 0.7305

CONS_SCORE: 0.4118

DSS_SCORE: 0.4544

HELIX: 0.217

FCONS_SCORE: 0.9522

RIG_SCORE: 0.7898

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R819H	TCGA-FI-A2D0	UCEC	TCGA	LDLHDD	LIG_APCC_ABBA_1	0.3056
p.R819H	DO50407	ESAD	ICGC	LDLHDD	LIG_APCC_ABBA_1	0.3056
p.R819H	DO43891	UCEC	ICGC	LDLHDD	LIG_APCC_ABBA_1	0.3056
p.D806N	DO45159	LIRI	ICGC	LDLHDD	LIG_APCC_ABBA_1	0.1389
p.H816R	DO231127	LUSC	ICGC	LDLHDD	LIG_APCC_ABBA_1	0.8244
p.T828N	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	LDLHDD	LIG_APCC_ABBA_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07157	Tight junction protein ZO-1	LIG_APCC_ABBA_1	813:818	LDLHDD	APC,CDC20,FZR1	0.9214	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons