DegronMD

Uniprot ID: O95400

Source protein: CD2 antigen cytoplasmic tail-binding protein 2

Source gene: CD2BP2

Class: LIG_APCC_ABBA_1

Location: 248:253

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.999

ASA_SCORE: 80.7333

COIL: 0.3618

CONS_SCORE: 0.4522

DSS_SCORE: 0.788

HELIX: 0.6313

FCONS_SCORE: 1.5634

RIG_SCORE: 0.7315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A256V	DO233127	GACA	ICGC	LDMFAE	LIG_APCC_ABBA_1	0.25
p.A256E	DO229035	LICA	ICGC	LDMFAE	LIG_APCC_ABBA_1	0.25
p.P239L	DO232761	PBCA	ICGC	LDMFAE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95400	CD2 antigen cytoplasmic tail-binding protein 2	LIG_APCC_ABBA_1	248:253	LDMFAE	APC,CDC20,FZR1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons