DegronMD

Uniprot ID: Q96S65

Source protein: Cysteine/serine-rich nuclear protein 1

Source gene: CSRNP1

Class: LIG_APCC_ABBA_1

Location: 567:572

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 73.7

COIL: 0.7982

CONS_SCORE: 0.4331

DSS_SCORE: 0.4712

HELIX: 0.1537

FCONS_SCORE: 1.0519

RIG_SCORE: 0.7898

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A564T	TCGA-AZ-6601	COAD	TCGA	LDPFID	LIG_APCC_ABBA_1	0.25
p.A564T	TCGA-B5-A11H	UCEC	TCGA	LDPFID	LIG_APCC_ABBA_1	0.25
p.A564T	DO8119	COAD	ICGC	LDPFID	LIG_APCC_ABBA_1	0.25
p.A564T	DO42825	UCEC	ICGC	LDPFID	LIG_APCC_ABBA_1	0.25
p.P569S	TCGA-DA-A3F3	SKCM	TCGA	LDPFID	LIG_APCC_ABBA_1	0.6752
p.P569S	TCGA-FS-A1Z3	SKCM	TCGA	LDPFID	LIG_APCC_ABBA_1	0.6752
p.P569S	DO228203	LICA	ICGC	LDPFID	LIG_APCC_ABBA_1	0.6752
p.P569S	DO222420	MELA	ICGC	LDPFID	LIG_APCC_ABBA_1	0.6752
p.P569S	DO37635	SKCM	ICGC	LDPFID	LIG_APCC_ABBA_1	0.6752
p.P569S	DO37607	SKCM	ICGC	LDPFID	LIG_APCC_ABBA_1	0.6752
p.S560C	TCGA-E7-A5KF	BLCA	TCGA	LDPFID	LIG_APCC_ABBA_1	0.1389
p.S560C	DO44038	BLCA	ICGC	LDPFID	LIG_APCC_ABBA_1	0.1389
p.A563D	DO229026	LICA	ICGC	LDPFID	LIG_APCC_ABBA_1	0.2222
p.Q574K	DO229037	LICA	ICGC	LDPFID	LIG_APCC_ABBA_1	0.2778
p.S582F	DO23540	LIRI	ICGC	LDPFID	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96S65	Cysteine/serine-rich nuclear protein 1	LIG_APCC_ABBA_1	567:572	LDPFID	APC,CDC20,FZR1	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons