DegronMD - Q96S65(CSRNP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R31P	TCGA-25-2392	OV	TCGA	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.R31P	DO28102	OV	ICGC	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.D10Y	TCGA-76-4934	GBM	TCGA	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0833
p.D10Y	DO12286	GBM	ICGC	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.0833
p.S18L	TCGA-AA-3811	COAD	TCGA	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.S18L	TCGA-E6-A1M0	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.S18L	DO7962	COAD	ICGC	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.S18L	DO43682	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.3056
p.A564T	TCGA-AZ-6601	COAD	TCGA	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.25
p.A564T	TCGA-B5-A11H	UCEC	TCGA	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.25
p.A564T	DO8119	COAD	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.25
p.A564T	DO42825	UCEC	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.25
p.R31H	TCGA-B5-A3FC	UCEC	TCGA	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.R31H	DO41871	UCEC	ICGC	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation rewiring degron network	0.1111
p.P569S	TCGA-DA-A3F3	SKCM	TCGA	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation altering degron motif	0.6752
p.P569S	TCGA-FS-A1Z3	SKCM	TCGA	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation altering degron motif	0.6752
p.P569S	DO228203	LICA	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation altering degron motif	0.6752
p.P569S	DO222420	MELA	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation altering degron motif	0.6752
p.P569S	DO37635	SKCM	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation altering degron motif	0.6752
p.P569S	DO37607	SKCM	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation altering degron motif	0.6752
p.S560C	TCGA-E7-A5KF	BLCA	TCGA	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.1389
p.S560C	DO44038	BLCA	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.1389
p.E313K	TCGA-EE-A2GB	SKCM	TCGA	SPGEEALVPTF	DEG_COP1_1	322:332	Mutation rewiring degron network	0.0833
p.E313K	DO222683	MELA	ICGC	SPGEEALVPTF	DEG_COP1_1	322:332	Mutation rewiring degron network	0.0833
p.E313K	DO37417	SKCM	ICGC	SPGEEALVPTF	DEG_COP1_1	322:332	Mutation rewiring degron network	0.0833
p.G318D	DO218535	BTCA	ICGC	SPGEEALVPTF	DEG_COP1_1	322:332	Mutation rewiring degron network	0.2222
p.P333Q	DO229025	LICA	ICGC	SPGEEALVPTF	DEG_COP1_1	322:332	Mutation rewiring degron network	0.3056
p.A563D	DO229026	LICA	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.2222
p.Q574K	DO229037	LICA	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.2778
p.S582F	DO23540	LIRI	ICGC	LDPFID	LIG_APCC_ABBA_1	567:572	Mutation rewiring degron network	0.0556
p.V19I	SIDM00622	Glioblastoma	GDSC	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7076
p.V19I	ACH-002224	Brain Cancer	CCLE	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7076
p.V19I	D-247MG	central nervous system	COSMIC	VSSSS	DEG_SPOP_SBC_1	19:23	Mutation altering degron motif	0.7076
p.M339I	ACH-002396	Bone Cancer	CCLE	SPGEEALVPTF	DEG_COP1_1	322:332	Mutation rewiring degron network	0.1389
p.M339I	Sarc9371	bone	COSMIC	SPGEEALVPTF	DEG_COP1_1	322:332	Mutation rewiring degron network	0.1389

Kaplan plot for CSRNP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSRNP1

UniProt ID: Q96S65

Entrez ID: 64651

Protein name: Cysteine/serine-rich nuclear protein 1 (CSRNP-1) (Axin-1 up-regulated gene 1 protein) (Protein URAX1) (TGF-beta-induced apoptosis protein 3) (TAIP-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSRNP1 in