DegronMD

Uniprot ID: Q96S65

Source protein: Cysteine/serine-rich nuclear protein 1

Source gene: CSRNP1

Class: DEG_COP1_1

Location: 322:332

E3 ligase: COP1

DEGRON score: 0.9881

ASA_SCORE: 81.2091

COIL: 0.8345

CONS_SCORE: 0.393

DSS_SCORE: 0.7299

HELIX: 0.1211

FCONS_SCORE: 1.0704

RIG_SCORE: 0.6337

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P333Q	DO229025	LICA	ICGC	SPGEEALVPTF	DEG_COP1_1	0.3056
p.G318D	DO218535	BTCA	ICGC	SPGEEALVPTF	DEG_COP1_1	0.2222
p.M339I	ACH-002396	Bone Cancer	CCLE	SPGEEALVPTF	DEG_COP1_1	0.1389
p.M339I	Sarc9371	bone	COSMIC	SPGEEALVPTF	DEG_COP1_1	0.1389
p.E313K	TCGA-EE-A2GB	SKCM	TCGA	SPGEEALVPTF	DEG_COP1_1	0.0833
p.E313K	DO222683	MELA	ICGC	SPGEEALVPTF	DEG_COP1_1	0.0833
p.E313K	DO37417	SKCM	ICGC	SPGEEALVPTF	DEG_COP1_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96S65	Cysteine/serine-rich nuclear protein 1	DEG_COP1_1	322:332	SPGEEALVPTF	COP1	0.9881	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons