DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SPGEEALVPTF
Uniprot ID:
Q96S65
Source protein:
Cysteine/serine-rich nuclear protein 1
Source gene:
CSRNP1
Class:
DEG_COP1_1
Location:
322:332
E3 ligase:
COP1
DEGRON score:
0.9881
ASA_SCORE:
81.2091
COIL:
0.8345
CONS_SCORE:
0.393
DSS_SCORE:
0.7299
HELIX:
0.1211
FCONS_SCORE:
1.0704
RIG_SCORE:
0.6337
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E313K
TCGA-EE-A2GB
SKCM
TCGA
SPGEEALVPTF
DEG_COP1_1
0.0833
p.E313K
DO222683
MELA
ICGC
SPGEEALVPTF
DEG_COP1_1
0.0833
p.E313K
DO37417
SKCM
ICGC
SPGEEALVPTF
DEG_COP1_1
0.0833
p.G318D
DO218535
BTCA
ICGC
SPGEEALVPTF
DEG_COP1_1
0.2222
p.P333Q
DO229025
LICA
ICGC
SPGEEALVPTF
DEG_COP1_1
0.3056
p.M339I
ACH-002396
Bone Cancer
CCLE
SPGEEALVPTF
DEG_COP1_1
0.1389
p.M339I
Sarc9371
bone
COSMIC
SPGEEALVPTF
DEG_COP1_1
0.1389
Drug responses associated with CSRNP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SPGEEALVPTF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96S65
Cysteine/serine-rich nuclear protein 1
DEG_COP1_1
322:332
SPGEEALVPTF
COP1
0.9881
More...