DegronMD

Uniprot ID: Q9UL68

Source protein: Myelin transcription factor 1-like protein

Source gene: MYT1L

Class: LIG_APCC_ABBA_1

Location: 844:849

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9879

ASA_SCORE: 79.55

COIL: 0.5573

CONS_SCORE: 0.4661

DSS_SCORE: 0.6406

HELIX: 0.4075

FCONS_SCORE: 1.0723

RIG_SCORE: 0.7464

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E840G	TCGA-18-3409	LUSC	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.2222
p.E840G	DO26444	LUSC	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.2222
p.P855R	TCGA-50-5045	LUAD	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.1667
p.P855R	DO23723	LUAD	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.1667
p.R852T	TCGA-AO-A0JE	BRCA	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.25
p.R852T	TCGA-XF-A9T8	BLCA	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.25
p.R852T	DO51927	BLCA	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.25
p.R852T	DO3650	BRCA	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.25
p.D841N	TCGA-BF-AAOX	SKCM	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.25
p.D841N	DO223907	SKCM	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.25
p.R853P	TCGA-CV-A461	HNSC	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.2222
p.R853P	DO49058	HNSC	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.2222
p.E847V	TCGA-DU-6392	LGG	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.7693
p.E847V	DO22237	LGG	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.7693
p.E857K	TCGA-EE-A2GC	SKCM	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.1111
p.E857K	DO37839	SKCM	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.1111
p.A848V	TCGA-VS-A9UC	CESC	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.6936
p.A848V	DO219732	CESC	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.6936
p.P844T	TCGA-WE-A8ZY	SKCM	TCGA	LDPFQE	LIG_APCC_ABBA_1	0.7031
p.P844T	DO51292	SKCM	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.7031
p.D843N	DO50410	ESAD	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.3056
p.R853Q	DO233076	GACA	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.2222
p.P855T	DO228976	LICA	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.1667
p.A848D	DO228978	LICA	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.7793
p.D841E	DO229028	LICA	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.25
p.E850K	DO220895	MELA	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.3056
p.E840Q	DO229546	UTCA	ICGC	LDPFQE	LIG_APCC_ABBA_1	0.2222
p.E842D	SIDM01117	Small Cell Lung Carcinoma	GDSC	LDPFQE	LIG_APCC_ABBA_1	0.2778
p.E842D	NCI-H748	lung	COSMIC	LDPFQE	LIG_APCC_ABBA_1	0.2778
p.G858W	SIDM01121	Small Cell Lung Carcinoma	GDSC	LDPFQE	LIG_APCC_ABBA_1	0.0833
p.G858W	NCI-H69	lung	COSMIC	LDPFQE	LIG_APCC_ABBA_1	0.0833
p.G856W	ACH-000358	Lung Cancer	CCLE	LDPFQE	LIG_APCC_ABBA_1	0.1389
p.G856W	NCI-H69	lung	COSMIC	LDPFQE	LIG_APCC_ABBA_1	0.1389
p.T859I	ACH-000995	Leukemia	CCLE	LDPFQE	LIG_APCC_ABBA_1	0.0556
p.T859I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LDPFQE	LIG_APCC_ABBA_1	0.0556
p.E840D	ACH-002176	Lung Cancer	CCLE	LDPFQE	LIG_APCC_ABBA_1	0.2222
p.E840D	NCI-H748	lung	COSMIC	LDPFQE	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDPFQE

Degron related mutations and impact score

Drug responses associated with MYT1L mutations

All proteins holding degron of LDPFQE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UL68	Myelin transcription factor 1-like protein	LIG_APCC_ABBA_1	844:849	LDPFQE	APC,CDC20,FZR1	0.9879	More...