DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LDTPEKT
Uniprot ID:
Q9BYG3
Source protein:
MKI67 FHA domain-interacting nucleolar phosphoprotein
Source gene:
NIFK
Class:
DEG_SCF_FBW7_1
Location:
221:227
E3 ligase:
FBXW7
DEGRON score:
0.9901
ASA_SCORE:
110.7143
COIL:
0.9277
CONS_SCORE:
0.2806
DSS_SCORE:
0.614
HELIX:
0.0391
FCONS_SCORE:
1.0026
RIG_SCORE:
0.6842
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T227N
TCGA-AX-A2HD
UCEC
TCGA
LDTPEKT
DEG_SCF_FBW7_1
0.8166
p.G232D
TCGA-BR-4184
STAD
TCGA
LDTPEKT
DEG_SCF_FBW7_1
0.1944
Drug responses associated with NIFK mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LDTPEKT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9BYG3
MKI67 FHA domain-interacting nucleolar phosphoprotein
DEG_SCF_FBW7_1
221:227
LDTPEKT
FBXW7
0.9901
More...