DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SCF_FBW7_1

Location: 1127:1134

E3 ligase: FBXW7

DEGRON score: 0.9248

ASA_SCORE: 78.225

COIL: 0.8205

CONS_SCORE: 0.3978

DSS_SCORE: 0.7494

HELIX: 0.06

FCONS_SCORE: -0.0022

RIG_SCORE: 0.6448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1139H	DO23610	LUAD	ICGC	LDTTPYSS	DEG_SCF_FBW7_1	0.1944
p.S1140F	SIDM01002	Breast Carcinoma	GDSC	LDTTPYSS	DEG_SCF_FBW7_1	0.1667
p.S1140F	ACH-000117	Breast Cancer	CCLE	LDTTPYSS	DEG_SCF_FBW7_1	0.1667
p.S1140F	EFM-192A	breast	COSMIC	LDTTPYSS	DEG_SCF_FBW7_1	0.1667
p.S1140Y	ACH-001846	Bile Duct Cancer	CCLE	LDTTPYSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SCF_FBW7_1	1127:1134	LDTTPYSS	FBXW7	0.9248	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons