DegronMD

Uniprot ID: Q9Y6G9

Source protein: Cytoplasmic dynein 1 light intermediate chain 1

Source gene: DYNC1LI1

Class: LIG_APCC_ABBA_1

Location: 493:498

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9964

ASA_SCORE: 78.65

COIL: 0.3788

CONS_SCORE: 0.4144

DSS_SCORE: 0.6489

HELIX: 0.5882

FCONS_SCORE: 1.217

RIG_SCORE: 0.7765

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D500Y	TCGA-AP-A1DV	UCEC	TCGA	LDVHAE	LIG_APCC_ABBA_1	0.2778
p.G488C	TCGA-BF-A1PZ	SKCM	TCGA	LDVHAE	LIG_APCC_ABBA_1	0.1944
p.R504Q	TCGA-BR-8680	STAD	TCGA	LDVHAE	LIG_APCC_ABBA_1	0.1667
p.R501K	TCGA-F5-6814	READ	TCGA	LDVHAE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6G9	Cytoplasmic dynein 1 light intermediate chain 1	LIG_APCC_ABBA_1	493:498	LDVHAE	APC,CDC20,FZR1	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons