DegronMD - Q9Y6G9(DYNC1LI1)

DYNC1LI1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S419N	TCGA-AP-A1DK	UCEC	TCGA	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation blocking phosphorylation signal	0.5833
p.D500Y	TCGA-AP-A1DV	UCEC	TCGA	LDVHAE	LIG_APCC_ABBA_1	493:498	Mutation rewiring degron network	0.2778
p.G488C	TCGA-BF-A1PZ	SKCM	TCGA	LDVHAE	LIG_APCC_ABBA_1	493:498	Mutation rewiring degron network	0.1944
p.R504Q	TCGA-BR-8680	STAD	TCGA	LDVHAE	LIG_APCC_ABBA_1	493:498	Mutation rewiring degron network	0.1667
p.P422H	TCGA-DA-A1I5	SKCM	TCGA	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation rewiring degron network	0.0556
p.R501K	TCGA-F5-6814	READ	TCGA	LDVHAE	LIG_APCC_ABBA_1	493:498	Mutation rewiring degron network	0.25
p.T399A	DO44055	BLCA	ICGC	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation rewiring degron network	0.1389
p.T399A	HTC-C3	thyroid	COSMIC	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation rewiring degron network	0.1389
p.E403K	DO52207	LIHC	ICGC	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation rewiring degron network	0.25
p.S407F	DO220887	MELA	ICGC	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation altering degron motif	0.7982
p.P401S	DO222415	MELA	ICGC	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation rewiring degron network	0.1944
p.R400K	SIDM01577	Plasma Cell Myeloma	GDSC	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation rewiring degron network	0.1667
p.R400K	ACH-000889	Myeloma	CCLE	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation rewiring degron network	0.1667
p.P406Q	ACH-000020	Leukemia	CCLE	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation altering degron motif	0.7035
p.T402M	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PRTPNRS	DEG_SCF_FBW7_1	406:412	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc