DegronMD

Uniprot ID: Q9Y6G9

Source protein: Cytoplasmic dynein 1 light intermediate chain 1

Source gene: DYNC1LI1

Class: DEG_SCF_FBW7_1

Location: 406:412

E3 ligase: FBXW7

DEGRON score: 0.9877

ASA_SCORE: 103.1571

COIL: 0.9261

CONS_SCORE: 0.2788

DSS_SCORE: 0.6889

HELIX: 0.0359

FCONS_SCORE: 0.999

RIG_SCORE: 0.5645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S419N	TCGA-AP-A1DK	UCEC	TCGA	PRTPNRS	DEG_SCF_FBW7_1	0.5833
p.P422H	TCGA-DA-A1I5	SKCM	TCGA	PRTPNRS	DEG_SCF_FBW7_1	0.0556
p.T399A	DO44055	BLCA	ICGC	PRTPNRS	DEG_SCF_FBW7_1	0.1389
p.T399A	HTC-C3	thyroid	COSMIC	PRTPNRS	DEG_SCF_FBW7_1	0.1389
p.E403K	DO52207	LIHC	ICGC	PRTPNRS	DEG_SCF_FBW7_1	0.25
p.S407F	DO220887	MELA	ICGC	PRTPNRS	DEG_SCF_FBW7_1	0.7982
p.P401S	DO222415	MELA	ICGC	PRTPNRS	DEG_SCF_FBW7_1	0.1944
p.R400K	SIDM01577	Plasma Cell Myeloma	GDSC	PRTPNRS	DEG_SCF_FBW7_1	0.1667
p.R400K	ACH-000889	Myeloma	CCLE	PRTPNRS	DEG_SCF_FBW7_1	0.1667
p.P406Q	ACH-000020	Leukemia	CCLE	PRTPNRS	DEG_SCF_FBW7_1	0.7035
p.T402M	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PRTPNRS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6G9	Cytoplasmic dynein 1 light intermediate chain 1	DEG_SCF_FBW7_1	406:412	PRTPNRS	FBXW7	0.9877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons