DegronMD

Uniprot ID: P33993

Source protein: DNA replication licensing factor MCM7

Source gene: MCM7

Class: LIG_APCC_ABBA_1

Location: 99:104

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8418

ASA_SCORE: 57.4833

COIL: 0.0827

CONS_SCORE: 0.5279

DSS_SCORE: 0.2019

HELIX: 0.9048

FCONS_SCORE: 1.2225

RIG_SCORE: 0.8978

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D100N	TCGA-AP-A1DV	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.5821
p.D100N	DO43186	UCEC	ICGC	LDVYIE	LIG_APCC_ABBA_1	0.5821
p.R114W	TCGA-AX-A2HD	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.0556
p.R106Q	TCGA-AX-A2HD	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.2778
p.R106Q	DO42608	UCEC	ICGC	LDVYIE	LIG_APCC_ABBA_1	0.2778
p.E90D	TCGA-BP-5187	KIRC	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.0833
p.E90D	DO17633	KIRC	ICGC	LDVYIE	LIG_APCC_ABBA_1	0.0833
p.Q111L	TCGA-BR-8487	STAD	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.1389
p.R112Q	TCGA-CD-A4MG	STAD	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.1111
p.R112Q	DO48009	STAD	ICGC	LDVYIE	LIG_APCC_ABBA_1	0.1111
p.R112Q	ACH-001685	Lymphoma	CCLE	LDVYIE	LIG_APCC_ABBA_1	0.1111
p.E110K	TCGA-CR-5248	HNSC	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.1667
p.E110K	DO14694	HNSC	ICGC	LDVYIE	LIG_APCC_ABBA_1	0.1667
p.S113N	TCGA-D1-A103	UCEC	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.5278
p.S113N	DO42312	UCEC	ICGC	LDVYIE	LIG_APCC_ABBA_1	0.5278
p.V98G	TCGA-P5-A730	LGG	TCGA	LDVYIE	LIG_APCC_ABBA_1	0.3056
p.V98G	DO219830	LGG	ICGC	LDVYIE	LIG_APCC_ABBA_1	0.3056
p.D97H	DO225343	BRCA	ICGC	LDVYIE	LIG_APCC_ABBA_1	0.2778
p.R112W	SIDM00980	Gastric Carcinoma	GDSC	LDVYIE	LIG_APCC_ABBA_1	0.1111
p.R112W	ACH-000948	Gastric Cancer	CCLE	LDVYIE	LIG_APCC_ABBA_1	0.1111
p.R112W	23132-87	stomach	COSMIC	LDVYIE	LIG_APCC_ABBA_1	0.1111
p.Y102H	SIDM01608	Endometrial Carcinoma	GDSC	LDVYIE	LIG_APCC_ABBA_1	0.7229
p.Y102H	ACH-000990	Endometrial/Uterine Cancer	CCLE	LDVYIE	LIG_APCC_ABBA_1	0.7229
p.G108R	LS-411N	large_intestine	COSMIC	LDVYIE	LIG_APCC_ABBA_1	0.2222
p.R106C	TE-4	oesophagus	COSMIC	LDVYIE	LIG_APCC_ABBA_1	0.2778
p.R106C	KYAE-1	oesophagus	COSMIC	LDVYIE	LIG_APCC_ABBA_1	0.2778
p.V97I	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	LDVYIE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P33993	DNA replication licensing factor MCM7	LIG_APCC_ABBA_1	99:104	LDVYIE	APC,CDC20,FZR1	0.8418	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LDVYIE

Degron related mutations and impact score

Drug responses associated with MCM7 mutations

All proteins holding degron of LDVYIE