DegronMD

Uniprot ID: Q9Y2M0

Source protein: Fanconi-associated nuclease 1

Source gene: FAN1

Class: DEG_SCF_SKP2-CKS1_1

Location: 94:101

E3 ligase: SKP2,CSK1

DEGRON score: 0.9818

ASA_SCORE: 112.3625

COIL: 0.8696

CONS_SCORE: 0.2403

DSS_SCORE: 0.5825

HELIX: 0.1084

FCONS_SCORE: 1.0496

RIG_SCORE: 0.7086

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V92I	TCGA-A6-6653	COAD	TCGA	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.2778
p.V92I	DO10373	COAD	ICGC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.2778
p.P99S	TCGA-AX-A1CE	UCEC	TCGA	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.6752
p.P99S	DO42280	UCEC	ICGC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.6752
p.V97I	TCGA-D1-A0ZP	UCEC	TCGA	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.5965
p.V97I	DO42233	UCEC	ICGC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.5965
p.M86I	TCGA-FS-A1ZN	SKCM	TCGA	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.1111
p.M86I	DO38165	SKCM	ICGC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.1111
p.T93A	SIDM00660	Colorectal Carcinoma	GDSC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.T93A	ACH-000985	Colon/Colorectal Cancer	CCLE	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.3056
p.T93A	LS-411N	large_intestine	COSMIC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2M0	Fanconi-associated nuclease 1	DEG_SCF_SKP2-CKS1_1	94:101	LEDVTPKK	SKP2,CSK1	0.9818	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons