DegronMD - Q9Y2M0(FAN1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E120G	TCGA-17-Z030	LUAD	TCGA	LTPGQS	DEG_SCF_FBW7_1	109:114	Mutation rewiring degron network	0.1667
p.A261V	TCGA-95-7567	LUAD	TCGA	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.A261V	TCGA-A5-A0G2	UCEC	TCGA	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.A261V	TCGA-BR-8284	STAD	TCGA	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.A261V	DO25564	LUAD	ICGC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.A261V	DO38491	STAD	ICGC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.A261V	DO41235	UCEC	ICGC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.A261V	SIDM00164	Biliary Tract Carcinoma	GDSC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.A261V	ACH-000209	Bile Duct Cancer	CCLE	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.25
p.V92I	TCGA-A6-6653	COAD	TCGA	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation rewiring degron network	0.1944
p.V92I	TCGA-A6-6653	COAD	TCGA	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation rewiring degron network	0.2778
p.V92I	DO10373	COAD	ICGC	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation rewiring degron network	0.1944
p.V92I	DO10373	COAD	ICGC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation rewiring degron network	0.2778
p.T245A	TCGA-AP-A05N	UCEC	TCGA	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.1111
p.T245A	DO40851	UCEC	ICGC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.1111
p.P99S	TCGA-AX-A1CE	UCEC	TCGA	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation altering degron motif	0.6752
p.P99S	TCGA-AX-A1CE	UCEC	TCGA	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation altering degron motif	0.6752
p.P99S	DO42280	UCEC	ICGC	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation altering degron motif	0.6752
p.P99S	DO42280	UCEC	ICGC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation altering degron motif	0.6752
p.V97I	TCGA-D1-A0ZP	UCEC	TCGA	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation altering degron motif	0.5965
p.V97I	TCGA-D1-A0ZP	UCEC	TCGA	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation altering degron motif	0.5965
p.V97I	DO42233	UCEC	ICGC	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation altering degron motif	0.5965
p.V97I	DO42233	UCEC	ICGC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation altering degron motif	0.5965
p.P111T	TCGA-EE-A2MM	SKCM	TCGA	LTPGQS	DEG_SCF_FBW7_1	109:114	Mutation altering degron motif	0.7031
p.P111T	DO37770	SKCM	ICGC	LTPGQS	DEG_SCF_FBW7_1	109:114	Mutation altering degron motif	0.7031
p.E249D	TCGA-EY-A1GI	UCEC	TCGA	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.2222
p.E249D	TCGA-ND-A4WC	UCS	TCGA	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.2222
p.E249D	DO222762	COCA	ICGC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.2222
p.E249D	DO41211	UCEC	ICGC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.2222
p.M86I	TCGA-FS-A1ZN	SKCM	TCGA	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation rewiring degron network	0.1111
p.M86I	DO38165	SKCM	ICGC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation rewiring degron network	0.1111
p.D259H	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.3056
p.D259H	ACH-000521	Lung Cancer	CCLE	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.3056
p.D259H	NCI-H2030	lung	COSMIC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation rewiring degron network	0.3056
p.T93A	SIDM00660	Colorectal Carcinoma	GDSC	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation rewiring degron network	0.2222
p.T93A	SIDM00660	Colorectal Carcinoma	GDSC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation rewiring degron network	0.3056
p.T93A	ACH-000985	Colon/Colorectal Cancer	CCLE	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation rewiring degron network	0.2222
p.T93A	ACH-000985	Colon/Colorectal Cancer	CCLE	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation rewiring degron network	0.3056
p.T93A	LS-411N	large intestine	COSMIC	VTPKKS	DEG_SCF_FBW7_1	97:102	Mutation rewiring degron network	0.2222
p.T93A	LS-411N	large intestine	COSMIC	LEDVTPKK	DEG_SCF_SKP2-CKS1_1	94:101	Mutation rewiring degron network	0.3056
p.L109S	SIDM00210	Ovarian Carcinoma	GDSC	LTPGQS	DEG_SCF_FBW7_1	109:114	Mutation altering degron motif	0.7667
p.L109S	SIDM00068	Colorectal Carcinoma	GDSC	LTPGQS	DEG_SCF_FBW7_1	109:114	Mutation altering degron motif	0.7667
p.L109S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LTPGQS	DEG_SCF_FBW7_1	109:114	Mutation altering degron motif	0.7667
p.L253I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.6063
p.L253I	ACH-000980	Lung Cancer	CCLE	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.6063
p.L253I	NCI-H1155	lung	COSMIC	LTPGFS	DEG_SCF_FBW7_1	253:258	Mutation altering degron motif	0.6063

Kaplan plot for FAN1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAN1

UniProt ID: Q9Y2M0

Entrez ID: 22909

Protein name: Fanconi-associated nuclease 1 (EC 3.1.21.-) (EC 3.1.4.1) (FANCD2/FANCI-associated nuclease 1) (hFAN1) (Myotubularin-related protein 15)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAN1 in