DegronMD

Uniprot ID: Q9Y2M0

Source protein: Fanconi-associated nuclease 1

Source gene: FAN1

Class: DEG_SCF_FBW7_1

Location: 253:258

E3 ligase: FBXW7

DEGRON score: 0.9996

ASA_SCORE: 70.9167

COIL: 0.8805

CONS_SCORE: 0.2444

DSS_SCORE: 0.3579

HELIX: 0.0805

FCONS_SCORE: 1.0819

RIG_SCORE: 0.7187

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A261V	TCGA-95-7567	LUAD	TCGA	LTPGFS	DEG_SCF_FBW7_1	0.25
p.A261V	TCGA-A5-A0G2	UCEC	TCGA	LTPGFS	DEG_SCF_FBW7_1	0.25
p.A261V	TCGA-BR-8284	STAD	TCGA	LTPGFS	DEG_SCF_FBW7_1	0.25
p.A261V	DO25564	LUAD	ICGC	LTPGFS	DEG_SCF_FBW7_1	0.25
p.A261V	DO38491	STAD	ICGC	LTPGFS	DEG_SCF_FBW7_1	0.25
p.A261V	DO41235	UCEC	ICGC	LTPGFS	DEG_SCF_FBW7_1	0.25
p.A261V	SIDM00164	Biliary Tract Carcinoma	GDSC	LTPGFS	DEG_SCF_FBW7_1	0.25
p.A261V	ACH-000209	Bile Duct Cancer	CCLE	LTPGFS	DEG_SCF_FBW7_1	0.25
p.T245A	TCGA-AP-A05N	UCEC	TCGA	LTPGFS	DEG_SCF_FBW7_1	0.1111
p.T245A	DO40851	UCEC	ICGC	LTPGFS	DEG_SCF_FBW7_1	0.1111
p.E249D	TCGA-EY-A1GI	UCEC	TCGA	LTPGFS	DEG_SCF_FBW7_1	0.2222
p.E249D	TCGA-ND-A4WC	UCS	TCGA	LTPGFS	DEG_SCF_FBW7_1	0.2222
p.E249D	DO222762	COCA	ICGC	LTPGFS	DEG_SCF_FBW7_1	0.2222
p.E249D	DO41211	UCEC	ICGC	LTPGFS	DEG_SCF_FBW7_1	0.2222
p.D259H	SIDM00715	Non-Small Cell Lung Carcinoma	GDSC	LTPGFS	DEG_SCF_FBW7_1	0.3056
p.D259H	ACH-000521	Lung Cancer	CCLE	LTPGFS	DEG_SCF_FBW7_1	0.3056
p.D259H	NCI-H2030	lung	COSMIC	LTPGFS	DEG_SCF_FBW7_1	0.3056
p.L253I	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	LTPGFS	DEG_SCF_FBW7_1	0.6063
p.L253I	ACH-000980	Lung Cancer	CCLE	LTPGFS	DEG_SCF_FBW7_1	0.6063
p.L253I	NCI-H1155	lung	COSMIC	LTPGFS	DEG_SCF_FBW7_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2M0	Fanconi-associated nuclease 1	DEG_SCF_FBW7_1	253:258	LTPGFS	FBXW7	0.9996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons